Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
MA5-15431 targets MLH1 in indirect ELISA, IF, IHC, and WB applications and shows reactivity with Human and Non-human primate samples.
The MA5-15431 immunogen is purified recombinant fragment of MLH1 (aa381-483) expressed in E. Coli.
.
MA5-15431 detects MLH1 which has a predicted molecular weight of approximately 85kDa.
MLH1 is a DNA mismatch repair protein. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DNA mismatch repair protein Mlh1; MGC5172; MLH-1; mutL homolog 1, colon cancer, nonpolyposis type 2; MutL protein homolog 1
Gene Aliases: COCA2; FCC2; hMLH1; HNPCC; HNPCC2; MLH1
UniProt ID: (Human) P40692
Entrez Gene ID: (Human) 4292
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support