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Proteintech
MLK2 Polyclonal Antibody
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Product Details
19974-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody recognizes the N-term of MAP3K10. The antibody has no cross reaction to MAP3K9.
Target Information
MAP3K10 (MLK2) is a serine/threonine kinase which has been shown to activate MAPK8/JNK and MKK4/SEK1. This kinase itself can be phoshorylated, and is thus activated by JNK kinases. MAP3K10 functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MAP3K9; MEKK9; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; MLK1; PRKE1; Protein kinase MST
Gene Aliases: MAP3K10; MEKK10; MLK2; MST
UniProt ID: (Human) Q02779
Entrez Gene ID: (Human) 4294
apoptotic process
signal transduction
smoothened signaling pathway
JNK cascade
activation of JNKK activity
activation of JUN kinase activity
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
positive regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of JUN kinase activity
negative regulation of transcription, DNA-templated
positive regulation of JNK cascade
protein autophosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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