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Invitrogen
MLK2 Polyclonal Antibody
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FIGURE: 1 / 1
MLK2 Antibody (PA5-75848) in WB
Western blot analysis of MLK2 in Lane 1: HEK293T whole cell lysate, Lane 2: RAW264.7 whole cell lysate, Lane 3: H9C2 whole cell lysate, Lane 4: HeLa whole cell lysate. Samples were incubated with MLK2 polyclonal antibody (Product # PA5-75848) at a dilution of 1:500.
Product Details
PA5-75848
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues in Human MLK2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
MAP3K10 (MLK2) is a serine/threonine kinase which has been shown to activate MAPK8/JNK and MKK4/SEK1. This kinase itself can be phoshorylated, and is thus activated by JNK kinases. MAP3K10 functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MAP3K9; MEKK9; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; mixed-lineage kinase 2; MKN28 derived nonreceptor_type; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; MLK1; PRKE1; Protein kinase MST; serine/threonine kinase
Gene Aliases: BC028668; BC046514; MAP3K10; MEKK10; MLK2; MST
UniProt ID: (Human) Q02779, (Mouse) Q66L42
Entrez Gene ID: (Human) 4294, (Rat) 308463, (Mouse) 269881
transcription corepressor activity
protein kinase activity
protein serine/threonine kinase activity
JUN kinase kinase kinase activity
ATP binding
protein homodimerization activity
bHLH transcription factor binding
MAP kinase kinase kinase activity
nucleotide binding
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
apoptotic process
signal transduction
smoothened signaling pathway
JNK cascade
activation of JNKK activity
activation of JUN kinase activity
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
positive regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of JUN kinase activity
negative regulation of transcription, DNA-templated
positive regulation of JNK cascade
protein autophosphorylation
MAPK cascade
activation of MAPKK activity
protein phosphorylation
cell death
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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