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Invitrogen
MLL4 Polyclonal Antibody
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FIGURE: 1 / 2
MLL4 Antibody (PA5-40071) in WB
Western blot was performed on whole cell lysates from mouse embryonic stem cells (E14Tg2a) with the anti-mouse Mll4 antibody (Product # PA5-40071), diluted 1:500 in PBS-Tween containing 5% skimmed milk. The location of the protein of interest (~ 600 kDa) is indicated on the right; the location of the 500 kDa MW marker is shown on the left. Cells homozygous for the targeted mll4 allele (-/-) show a complete loss of Mll4 protein, whereas the Mll4 protein was detected in flp-recombined ES cells (F/F) and heterozygously targeted ES cells (+/-)... View More
Product Details
PA5-40071
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Three KLH-conjugated synthetic peptides containing an amino acid sequence from the central part of the protein corresponding to mouse Mll4 (Myeloid/lymphoid or mixed-lineage leukemia protein 4).
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Histone-lysine N-methyltransferase 2B; histone-lysine N-methyltransferase MLL4; KMT2D; Lysine N-methyltransferase 2B; mixed lineage leukemia 2; Myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog; Trithorax homolog 2; WBP-7; WW domain binding protein 7; WW domain-binding protein 7
Gene Aliases: 2610014H22Rik; Kmt2b; mKIAA0304; Mll2; Trx2; Wbp7
UniProt ID: (Mouse) O08550
Entrez Gene ID: (Mouse) 75410
ovarian follicle development
transcription, DNA-templated
regulation of transcription, DNA-templated
oocyte differentiation
gene silencing
chromatin modification
ovulation
methylation
histone lysine methylation
histone H3-K4 methylation
regulation of histone H3-K4 methylation
histone H3-K4 trimethylation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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