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Invitrogen
MMP12 Polyclonal Antibody
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Product Details
PA5-19263
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (RPKTSVNLISS) corresponding to the internal amino acids of MMP12 (aa 313-324).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine and canine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22. 3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3.4.24.65; Macrophage elastase; Macrophage metalloelastase; matrix metallo protease; matrix metallopeptidase 12 (macrophage elastase); matrix metalloproteinase 12 (macrophage elastase); Matrix metalloproteinase-12; ME; MGC138506; MME; MMP; MMP-12; MMPs; unnamed protein product
Gene Aliases: HME; ME; MME; MMP-12; MMP12
UniProt ID: (Human) P39900
Entrez Gene ID: (Human) 4321
negative regulation of transcription from RNA polymerase II promoter
proteolysis
protein import into nucleus
positive regulation of gene expression
extracellular matrix disassembly
extracellular matrix organization
collagen catabolic process
positive regulation of interferon-alpha production
wound healing, spreading of epidermal cells
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
regulation of defense response to virus by host
positive regulation of epithelial cell proliferation involved in wound healing
elastin catabolic process
negative regulation of type I interferon-mediated signaling pathway
positive regulation of type I interferon-mediated signaling pathway
bronchiole development
cellular response to virus
response to amyloid-beta
negative regulation of endothelial cell-matrix adhesion via fibronectin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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