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Invitrogen
MMP14 Polyclonal Antibody
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FIGURE: 1 / 8
MMP14 Antibody (PA5-13183) in ICC/IF
Immunofluorescence analysis of MMP14 was performed using 70% confluent log phase MDA-MB-231 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with MMP14 Polyclonal Antibody (Product # PA5-13183) at 1:100 dilution in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product #... View More
Product Details
PA5-13183
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 145-174 amino acids from the N-terminal region of human MMP14
Conjugate
Form
Liquid
Concentration
2 mg/mL
Amount
800 µg
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, mouse, porcine and rat based on sequence homology.
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 3.4.24.80; matrix metallo protease; matrix metallopeptidase 14 (membrane-inserted); matrix metalloproteinase 14 (membrane-inserted); matrix metalloproteinase 14 membrane-inserted; matrix metalloproteinase 14, membrane-inserted; Matrix metalloproteinase-14; membrane type 1 metalloprotease; membrane type 1-matrix metalloproteinase; Membrane type 1-MMP; Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase; MMP; MMP-14; MMP-X MT-MMP; MMP-X1; MMPs; MT-MMP; MT-MMP 1; MT-MMP MT1-MMP; MT1-MMP; MT1MMP; MTMMP1; type 1 matrix metalloprotease 14; unnamed protein product
Gene Aliases: AI325305; MMP-14; MMP-X1; MMP14; MT-MMP; MT-MMP 1; MT-MMP-1; MT1-MMP; MT1MMP; Mtmmp; MTMMP1; sabe; WNCHRS
UniProt ID: (Human) P50281, (Mouse) P53690, (Rat) Q10739
Entrez Gene ID: (Human) 4323, (Mouse) 17387, (Rat) 81707
endopeptidase activity
metalloendopeptidase activity
serine-type endopeptidase activity
integrin binding
protein binding
peptidase activity
metallopeptidase activity
zinc ion binding
hydrolase activity
metal ion binding
metalloaminopeptidase activity
transcription factor activity, sequence-specific DNA binding
calcium ion binding
peptidase activator activity
metalloprotease
skeletal system development
ossification
angiogenesis
ovarian follicle development
response to hypoxia
endothelial cell proliferation
endochondral ossification
proteolysis
response to oxidative stress
male gonad development
response to mechanical stimulus
anatomical structure morphogenesis
response to hormone
positive regulation of myotube differentiation
positive regulation of protein processing
cell migration
protein processing
extracellular matrix disassembly
protein catabolic process
extracellular matrix organization
positive regulation of cell growth
lung development
positive regulation of cell migration
collagen catabolic process
zymogen activation
endodermal cell differentiation
chondrocyte proliferation
astrocyte cell migration
response to estrogen
positive regulation of B cell differentiation
negative regulation of Notch signaling pathway
embryonic cranial skeleton morphogenesis
branching morphogenesis of an epithelial tube
tissue remodeling
cell motility
negative regulation of focal adhesion assembly
head development
bone development
cellular response to genistein
craniofacial suture morphogenesis
GDF15-GFRAL signaling pathway
negative regulation of GDF15-GFRAL signaling pathway
regulation of protein localization to plasma membrane
positive regulation of macrophage migration
response to odorant
regulation of transcription, DNA-templated
positive regulation of peptidase activity
response to organic cyclic compound
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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