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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 145-174 amino acids from the N-terminal region of human MMP14|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:10-1:50|
|Immunohistochemistry (Paraffin) (IHC (P))||1:25|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
This antibody is predicted to react with bovine, mouse, porcine and rat based on sequence homology.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP14 seems to specifically activate progelatinase A, and may thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. Expression is significant in stromal cells of colon, breast, and head and neck.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2.
PA5-13183 was used in immunohistochemistry to investigate the expression of MMP-2,-7,-9,MT1-MMP, and TIMP-1 and -2 in ovarian tumors
|Brun JL,Cortez A,Commo F,Uzan S,Rouzier R,Daraï E||International journal of oncology (33:1239)||2008|
EC 184.108.40.206; matrix metallopeptidase 14 (membrane-inserted); Matrix metalloproteinase-14 [Precursor]; membrane type 1 metalloprotease; membrane-type-1 matrix metalloproteinase; MMP14; MT-MMP 1; MT1-MMP; MT1MMP; MTMMP1
MMP-14; MMP-X1; MMP14; MT-MMP; MT-MMP 1; MT1-MMP; MT1MMP; MTMMP1; WNCHRS