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Product Details
18237-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MMP28 Fusion Protein Ag12980 (194-393 aa encoded by BC002631)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific to MMP28.
Immunogen sequence: LGNAFDGPG GALAHAFLPR RGEAHFDQDE RWSLSRRRGR NLFVVLAHEI GHTLGLTHSP APRALMAPYY KRLGRDALLS WDDVLAVQSL YGKPLGGSVA VQLPGKLFTD FETWDSYSPQ GRRPETQGPK YCHSSFDAIT VDRQQQLYIF KGSHFWEVAA DGNVSEPRPL QERWVGLPPN IEAAAVSLND GDFYFFKVQS V (194-393 aa encoded by BC002631)
Target Information
Epilysin, also known as matrix metalloproteinase-28 (MMP-28), is a secreted protein that belongs to the peptidase M10A family. Matrix metalloproteinase proteins are responsible for the breakdown of the extracellular matrix which is important for normal physiological processes such as tissue remodeling, reproduction and embryonic development. Epilysin is produced by proliferating keratinocytes and is responsible for mediating the degradation of casein. Its expression is upregulated in response to injury of the skin suggesting that Epilysin may be involved in tissue repair and homeostasis. In addition, Epilysin may function predominantly in the nervous system. Incubation of Epilysin with rat embryonic brain tissue results in the degradation of myelin proteins. In Xenopus, Epilysin localizes to nerves and is upregulated during neurulation. This suggests that Epilysin plays an evolutionarily conserved role in neural development and may be involved in modulating the axonal-glial extracellular environment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Epilysin; matrix metallo protease; matrix metallopeptidase 28 (epilysin); matrix metalloprotease MMP25; matrix metalloproteinase 28 (epilysin); Matrix metalloproteinase-28; MMP; MMP-28; MMPs; PRO4339; UNQ1893
Gene Aliases: D130023P12; EPILYSIN; MM28; MMP-25; MMP-28; MMP25; MMP28; UNQ1893/PRO4339
UniProt ID: (Human) Q96TE2
Entrez Gene ID: (Human) 79148, (Rat) 303384, (Mouse) 118453
Performance Guarantee
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