Product References
Preparation of Melatonin-Loaded Nanoparticles with Targeting and Sustained Release Function and Their Application in Osteoarthritis.
International journal of molecular sciences
Liang H,Yan Y,Sun W,Ma X,Su Z,Liu Z,Chen Y,Yu B
Sun May 14 00:00:00 UTC 2023
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo.
Chinese journal of natural medicines
Teng L,Shen Y,Qu Y,Yang L,Yang Y,Jian X,Fan S,Zhang L,Fu Q
Wed Feb 01 00:00:00 UTC 2023
Duhuo Jisheng Decoction suppresses apoptosis and mitochondrial dysfunction in human nucleus pulposus cells by miR-494/SIRT3/mitophagy signal axis.
Journal of orthopaedic surgery and research
Liu W,Zhao X,Wu X
Wed Mar 08 00:00:00 UTC 2023
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
Journal of orthopaedic translation
Wang X,Tan Y,Liu F,Wang J,Liu F,Zhang Q,Li J
Wed Mar 01 00:00:00 UTC 2023
AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation.
Cell & bioscience
Cai J,Wang Y,Wang X,Ai Z,Li T,Pu X,Yang X,Yao Y,He J,Cheng SY,Yu T,Liu C,Yue S
Sun Jan 22 00:00:00 UTC 2023
Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis.
Nature genetics
Nee K,Ma D,Nguyen QH,Pein M,Pervolarakis N,Insua-Rodríguez J,Gong Y,Hernandez G,Alshetaiwi H,Williams J,Rauf M,Dave KR,Boyapati K,Hasnain A,Calderon C,Markaryan A,Edwards R,Lin E,Parajuli R,Zhou P,Nie Q,Shalabi S,LaBarge MA,Kessenbrock K
Sat Apr 01 00:00:00 UTC 2023
Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation.
Chemico-biological interactions
Qian X,Zhu L,Xu M,Liu H,Yu X,Shao Q,Qin J
Fri Sep 01 00:00:00 UTC 2023
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
Journal of orthopaedic translation
Lu R,Xu H,Deng X,Wang Y,He Z,Xu S,Liang S,Huang X,You H,Guo F,Cheng P,Chen AM
Wed Mar 01 00:00:00 UTC 2023
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Aging
Cui X,Liu X,Kong P,Du T,Li T,Yang G,Zhang W,Jing X,Wang W
Fri Mar 24 00:00:00 UTC 2023
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Aging
Cui X,Liu X,Kong P,Du T,Li T,Yang G,Zhang W,Jing X,Wang W
Fri Mar 24 00:00:00 UTC 2023
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
International immunopharmacology
Yang G,Liu X,Jing X,Wang J,Wang H,Chen F,Wang W,Shao Y,Cui X
Thu Jun 01 00:00:00 UTC 2023
Anti-inflammation and anti-aging mechanisms of mercaptopurine in vivo and in vitro.
Biochemical and biophysical research communications
Jia H,Vashisth MK,Ge Y,Dai Q,He F,Wang X
Sun Jan 01 00:00:00 UTC 2023
Isobavachalcone ameliorates the progression of osteoarthritis by suppressing NF-κB signaling pathway.
International immunopharmacology
Guo Q,Zhang M,Dong Y,Liu K,Wang D,Zheng J
Thu Jun 01 00:00:00 UTC 2023
Apigenin Inhibits the Progression of Osteoarthritis by Mediating Macrophage Polarization.
Molecules (Basel, Switzerland)
Ji X,Du W,Che W,Wang L,Zhao L
Fri Mar 24 00:00:00 UTC 2023
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Materials today. Bio
Dai Z,Xia C,Zhao T,Wang H,Tian H,Xu O,Zhu X,Zhang J,Chen P
Wed Feb 01 00:00:00 UTC 2023
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
International immunopharmacology
Shen PC,Huang SH,Liu ZM,Lu CC,Chou SH,Tien YC
Sat Jul 01 00:00:00 UTC 2023
Protective effects of Cu/Zn-SOD and Mn-SOD on UVC radiation-induced damage in NIH/3T3 cells and murine skin.
Acta histochemica
Chen D,Ai X,Li Y,Li Y,Ao Y,Rong J,Li G
Mon May 01 00:00:00 UTC 2023
The Effect of Gut Microbiota on the Progression of Intervertebral Disc Degeneration.
Orthopaedic surgery
Yao B,Cai Y,Wang W,Deng J,Zhao L,Han Z,Wan L
Wed Mar 01 00:00:00 UTC 2023
The Effect of Gut Microbiota on the Progression of Intervertebral Disc Degeneration.
Orthopaedic surgery
Yao B,Cai Y,Wang W,Deng J,Zhao L,Han Z,Wan L
Wed Mar 01 00:00:00 UTC 2023
Combination of hyperlipidemia and 17β-Estradiol induces TMJOA-like pathological changes in rats.
Oral diseases
Zhao Y,Gan YH
Wed Nov 01 00:00:00 UTC 2023
Stevioside targets the NF-κB and MAPK pathways for inhibiting inflammation and apoptosis of chondrocytes and ameliorates osteoarthritis in vivo.
International immunopharmacology
Cai T,Ye H,Jiang H,Lin C,Lou C,Wang W,Yan Z,Xue X,Pan X,Lin J
Wed Feb 01 00:00:00 UTC 2023
Stevioside targets the NF-κB and MAPK pathways for inhibiting inflammation and apoptosis of chondrocytes and ameliorates osteoarthritis in vivo.
International immunopharmacology
Cai T,Ye H,Jiang H,Lin C,Lou C,Wang W,Yan Z,Xue X,Pan X,Lin J
Wed Feb 01 00:00:00 UTC 2023
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Inflammation
Shen Y,Teng L,Qu Y,Huang Y,Peng Y,Tang M,Fu Q
Sat Apr 01 00:00:00 UTC 2023
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Inflammation
Shen Y,Teng L,Qu Y,Huang Y,Peng Y,Tang M,Fu Q
Sat Apr 01 00:00:00 UTC 2023
Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration.
Autophagy
Wang D,Shang Q,Mao J,Gao C,Wang J,Wang D,Wang H,Jia H,Peng P,Du M,Luo Z,Yang L
Fri Sep 01 00:00:00 UTC 2023
Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration.
Autophagy
Wang D,Shang Q,Mao J,Gao C,Wang J,Wang D,Wang H,Jia H,Peng P,Du M,Luo Z,Yang L
Fri Sep 01 00:00:00 UTC 2023
Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration.
Autophagy
Wang D,Shang Q,Mao J,Gao C,Wang J,Wang D,Wang H,Jia H,Peng P,Du M,Luo Z,Yang L
Fri Sep 01 00:00:00 UTC 2023
Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration.
Autophagy
Wang D,Shang Q,Mao J,Gao C,Wang J,Wang D,Wang H,Jia H,Peng P,Du M,Luo Z,Yang L
Fri Sep 01 00:00:00 UTC 2023
Dendrobium nobile Lindl Polysaccharides Attenuate UVB-induced Photodamage by Regulating Oxidative Stress, Inflammation and MMPs Expression in Mice Model.
Photochemistry and photobiology
Long Y,Wang W,Zhang Y,Zhang S,Li Z,Deng J,Li J
Thu Nov 02 00:00:00 UTC 2023
Dioscin alleviates the progression of osteoarthritis: an in vitro and in vivo study.
Journal of inflammation (London, England)
Ding Q,Zhang R,Sheng G,Wang T,Jing S,Ma T,Wang S,Zhao H,Wu H,Li W
Thu Apr 13 00:00:00 UTC 2023
Exploring the chondroprotective effect of Chaenomeles speciosa on Glucose-6-Phosphate Isomerase model mice using an integrated approach of network pharmacology and experimental validation.
Journal of ethnopharmacology
Duan Z,Jin C,Deng Y,Liu J,Gu C,Wang J,Cai X,Li S,Zhou Y
Thu Oct 05 00:00:00 UTC 2023
Mechanical overload induces TMJ disc degeneration via TRPV4 activation.
Oral diseases
Cui SJ,Yang FJ,Wang XD,Mao ZB,Gu Y
Thu Apr 27 00:00:00 UTC 2023
The Bcr-Abl inhibitor DCC-2036 inhibits necroptosis and ameliorates osteoarthritis by targeting RIPK1 and RIPK3 kinases.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Piao L,Wu D,Rui C,Yang Y,Liu S,Liu J,Jin Z,Zhang H,Feng X,Bai L
Mon May 01 00:00:00 UTC 2023
The Bcr-Abl inhibitor DCC-2036 inhibits necroptosis and ameliorates osteoarthritis by targeting RIPK1 and RIPK3 kinases.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Piao L,Wu D,Rui C,Yang Y,Liu S,Liu J,Jin Z,Zhang H,Feng X,Bai L
Mon May 01 00:00:00 UTC 2023
Identification of hub genes and pathways in lung metastatic colorectal cancer.
BMC cancer
Dai W,Guo C,Wang Y,Li Y,Xie R,Wu J,Yao B,Xie D,He L,Li Y,Huang H,Wang Y,Liu S
Thu Apr 06 00:00:00 UTC 2023
Enhancement and Repair of Degenerative Intervertebral Disc in Rats Using Platelet-Rich Plasma/Ferulic Acid Hydrogel.
Cartilage
Chai Q,Zhang B,Da Y,Wang W,Gao Y,Yao M,Zhu H,Yang X,Zhu Y
Fri Dec 01 00:00:00 UTC 2023
Analyses of Transcriptomics upon IL-1β-Stimulated Mouse Chondrocytes and the Protective Effect of Catalpol through the NOD2/NF-κB/MAPK Signaling Pathway.
Molecules (Basel, Switzerland)
Pang Y,Zhao L,Ji X,Guo K,Yin X
Tue Feb 07 00:00:00 UTC 2023
Indirubin protects chondrocytes and alleviates OA by inhibiting the MAPK and NF-κB pathways.
International immunopharmacology
Wang X,Guo Z,Lin J,Sun K,Wang G,Hou L,Xu J,Guo J,Zhang X,Guo F,Wei Y
Wed Feb 01 00:00:00 UTC 2023
Therapeutic effects of kefir peptides on adjuvant-induced arthritis in rats through anti-inflammation and downregulation of matrix metalloproteinases.
Life sciences
Chuang KC,Lai YW,Ko CH,Yen CC,Chen HL,Lan YW,Chen CF,Chen W,Chen CM
Wed Mar 15 00:00:00 UTC 2023
Desferoxamine protects against hemophilic arthropathy through the upregulation of HIF-1α-BNIP3 mediated mitophagy.
Life sciences
Lin J,Guo Z,Zheng Z,Hou L,Xu J,Liu Q,Du T,Guo F,Jing X
Sun Jan 01 00:00:00 UTC 2023
FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation.
Journal of experimental & clinical cancer research : CR
Pan Y,Liu J,Gao Y,Guo Y,Wang C,Liang Z,Wu M,Qian Y,Li Y,Shen J,Lu C,Ma S
Wed Mar 29 00:00:00 UTC 2023
Corynoline Alleviates Osteoarthritis Development via the Nrf2/NF-κB Pathway.
Oxidative medicine and cellular longevity
Li S,Shi Y,Zhang S,Li H,Ye Z,Kong J,Hong W,Tu Y,Ren J,Meftah Z,Xie C,Wang X,Zhang X
Wed Aug 10 00:00:00 UTC 2022
Gentiopicroside attenuates collagen-induced arthritis in mice via modulating the CD147/p38/NF-κB pathway.
International immunopharmacology
Jia N,Ma H,Zhang T,Wang L,Cui J,Zha Y,Ding Y,Wang J
Fri Jul 01 00:00:00 UTC 2022
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Apoptosis : an international journal on programmed cell death
Wu ZL,Chen YJ,Zhang GZ,Xie QQ,Wang KP,Yang X,Liu TC,Wang ZQ,Zhao GH,Zhang HH
Tue Feb 01 00:00:00 UTC 2022
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Apoptosis : an international journal on programmed cell death
Wu ZL,Chen YJ,Zhang GZ,Xie QQ,Wang KP,Yang X,Liu TC,Wang ZQ,Zhao GH,Zhang HH
Tue Feb 01 00:00:00 UTC 2022
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Apoptosis : an international journal on programmed cell death
Wu ZL,Chen YJ,Zhang GZ,Xie QQ,Wang KP,Yang X,Liu TC,Wang ZQ,Zhao GH,Zhang HH
Tue Feb 01 00:00:00 UTC 2022
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Apoptosis : an international journal on programmed cell death
Wu ZL,Chen YJ,Zhang GZ,Xie QQ,Wang KP,Yang X,Liu TC,Wang ZQ,Zhao GH,Zhang HH
Tue Feb 01 00:00:00 UTC 2022
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Apoptosis : an international journal on programmed cell death
Wu ZL,Chen YJ,Zhang GZ,Xie QQ,Wang KP,Yang X,Liu TC,Wang ZQ,Zhao GH,Zhang HH
Tue Feb 01 00:00:00 UTC 2022
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Apoptosis : an international journal on programmed cell death
Wu ZL,Chen YJ,Zhang GZ,Xie QQ,Wang KP,Yang X,Liu TC,Wang ZQ,Zhao GH,Zhang HH
Tue Feb 01 00:00:00 UTC 2022
KIF17 maintains the epithelial phenotype of breast cancer cells and curbs tumour metastasis.
Cancer letters
Li T,Zhai D,Zhang M,Ye R,Kuang X,Shao N,Bi J,Lin Y
Tue Nov 01 00:00:00 UTC 2022
CD40/TRAF1 decreases synovial cell apoptosis in patients with rheumatoid arthritis through JNK/NF-κB pathway.
Journal of bone and mineral metabolism
Cheng T,Wu J,Xu Y,Liu C,Zhang H,Wang M
Thu Sep 01 00:00:00 UTC 2022
Belinostat (PXD101) resists UVB irradiation-induced cellular senescence and skin photoaging.
Biochemical and biophysical research communications
Jia HJ,Ge Y,Xia J,Shi YL,Wang XB
Sun Oct 30 00:00:00 UTC 2022
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Frontiers in pharmacology
Shao Y,Sun L,Yang G,Wang W,Liu X,Du T,Chen F,Jing X,Cui X
Sat Oct 01 00:00:00 UTC 2022
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Frontiers in pharmacology
Shao Y,Sun L,Yang G,Wang W,Liu X,Du T,Chen F,Jing X,Cui X
Sat Oct 01 00:00:00 UTC 2022
The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling.
Cell death & disease
Li R,Guan Z,Bi S,Wang F,He L,Niu X,You Y,Liu Y,Ding Y,Siwko S,Wang N,Zhang Z,Jin Y,Luo J
Mon Feb 14 00:00:00 UTC 2022
The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling.
Cell death & disease
Li R,Guan Z,Bi S,Wang F,He L,Niu X,You Y,Liu Y,Ding Y,Siwko S,Wang N,Zhang Z,Jin Y,Luo J
Mon Feb 14 00:00:00 UTC 2022
The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling.
Cell death & disease
Li R,Guan Z,Bi S,Wang F,He L,Niu X,You Y,Liu Y,Ding Y,Siwko S,Wang N,Zhang Z,Jin Y,Luo J
Mon Feb 14 00:00:00 UTC 2022
The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling.
Cell death & disease
Li R,Guan Z,Bi S,Wang F,He L,Niu X,You Y,Liu Y,Ding Y,Siwko S,Wang N,Zhang Z,Jin Y,Luo J
Mon Feb 14 00:00:00 UTC 2022
Epigenetic Changes within the Annulus Fibrosus by DNA Methylation in Rat Intervertebral Disc Degeneration Model.
Cells
Hong JY,Kim H,Jeon WJ,Lee J,Yeo C,Lee YJ,Ha IH
Thu Nov 10 00:00:00 UTC 2022
180-W GreenLight laser photoselective vaporization with multiple triamcinolone acetonide injections for the treatment of bladder neck contractures.
Lasers in medical science
Sun X,Jin X,Leng K,Zhao Y,Zhang H
Sat Oct 01 00:00:00 UTC 2022
Natural product, bilobalide, improves joint health in rabbits with osteoarthritis by anti-matrix degradation and antioxidant activities.
Frontiers in veterinary science
Ma T,Chen H,Ruan H,Lv L,Yu Y,Jia L,Zhao J,Li X,Zang Y,Xu X,Zhang J,Gao L
Tue Nov 08 00:00:00 UTC 2022
Natural product, bilobalide, improves joint health in rabbits with osteoarthritis by anti-matrix degradation and antioxidant activities.
Frontiers in veterinary science
Ma T,Chen H,Ruan H,Lv L,Yu Y,Jia L,Zhao J,Li X,Zang Y,Xu X,Zhang J,Gao L
Tue Nov 08 00:00:00 UTC 2022
FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis.
Bone research
Guo D,Lin C,Lu Y,Guan H,Qi W,Zhang H,Shao Y,Zeng C,Zhang R,Zhang H,Bai X,Cai D
Wed Jun 22 00:00:00 UTC 2022
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
International immunopharmacology
Qu Y,Shen Y,Teng L,Huang Y,Yang Y,Jian X,Fan S,Wu P,Fu Q
Sat Oct 01 00:00:00 UTC 2022
Ginkgolide C slows the progression of osteoarthritis by activating Nrf2/HO-1 and blocking the NF-κB pathway.
Frontiers in pharmacology
Ma T,Jia L,Zhao J,Lv L,Yu Y,Ruan H,Song X,Chen H,Li X,Zhang J,Gao L
Fri Nov 18 00:00:00 UTC 2022
Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage.
Journal of bone and mineral metabolism
Zhao Y,Guo Y,Sun M,Hussion S,Zheng Y,Huang H,Huo X,Zhao Y,Zhang F,Han Y,Ning Q,Xu P,Sun J,Lu S
Tue Nov 01 00:00:00 UTC 2022
Glycyrrhizin regulates rat TMJOA progression by inhibiting the HMGB1-RAGE/TLR4-NF-κB/AKT pathway.
Journal of cellular and molecular medicine
Hu Z,Xiao M,Cai H,Li W,Fang W,Long X
Tue Feb 01 00:00:00 UTC 2022
Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes.
Free radical biology & medicine
Wang W,Jing X,Du T,Ren J,Liu X,Chen F,Shao Y,Sun S,Yang G,Cui X
Thu Sep 01 00:00:00 UTC 2022
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Frontiers in endocrinology
Lu R,He Z,Zhang W,Wang Y,Cheng P,Lv Z,Yuan X,Guo F,You H,Chen AM,Hu W
Tue Dec 20 00:00:00 UTC 2022
Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.
Experimental & molecular medicine
Wang J,Xia D,Lin Y,Xu W,Wu Y,Chen J,Chu J,Shen P,Weng S,Wang X,Shen L,Fan S,Shen S
Tue Mar 01 00:00:00 UTC 2022
Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.
Experimental & molecular medicine
Wang J,Xia D,Lin Y,Xu W,Wu Y,Chen J,Chu J,Shen P,Weng S,Wang X,Shen L,Fan S,Shen S
Tue Mar 01 00:00:00 UTC 2022
Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.
Experimental & molecular medicine
Wang J,Xia D,Lin Y,Xu W,Wu Y,Chen J,Chu J,Shen P,Weng S,Wang X,Shen L,Fan S,Shen S
Tue Mar 01 00:00:00 UTC 2022
Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.
Experimental & molecular medicine
Wang J,Xia D,Lin Y,Xu W,Wu Y,Chen J,Chu J,Shen P,Weng S,Wang X,Shen L,Fan S,Shen S
Tue Mar 01 00:00:00 UTC 2022
Possible Repositioning of an Oral Anti-Osteoporotic Drug, Ipriflavone, for Treatment of Inflammatory Arthritis via Inhibitory Activity of KIAA1199, a Novel Potent Hyaluronidase.
International journal of molecular sciences
Koike H,Nishida Y,Shinomura T,Ohkawara B,Ohno K,Zhuo L,Kimata K,Ushida T,Imagama S
Thu Apr 07 00:00:00 UTC 2022
Flavokawain A alleviates the progression of mouse osteoarthritis: An in vitro and in vivo study.
Frontiers in bioengineering and biotechnology
Jing S,Wan J,Wang T,He Z,Ding Q,Sheng G,Wang S,Zhao H,Zhu Z,Wu H,Li W
Fri Dec 23 00:00:00 UTC 2022
Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system.
Journal of nanobiotechnology
Liao Z,Ke W,Liu H,Tong B,Wang K,Feng X,Hua W,Wang B,Song Y,Luo R,Liang H,Zhang W,Zhao K,Li S,Yang C
Mon Sep 19 00:00:00 UTC 2022
Increased Expression of Prolyl Endopeptidase Induced by Oxidative Stress in Nucleus Pulposus Cells Aggravates Intervertebral Disc Degeneration.
Oxidative medicine and cellular longevity
Zheng HL,Xu WN,Chen PB,Jiang LS,Zheng XF,Jiang SD
Tue Apr 26 00:00:00 UTC 2022
Increased Expression of Prolyl Endopeptidase Induced by Oxidative Stress in Nucleus Pulposus Cells Aggravates Intervertebral Disc Degeneration.
Oxidative medicine and cellular longevity
Zheng HL,Xu WN,Chen PB,Jiang LS,Zheng XF,Jiang SD
Tue Apr 26 00:00:00 UTC 2022
Increased Expression of Prolyl Endopeptidase Induced by Oxidative Stress in Nucleus Pulposus Cells Aggravates Intervertebral Disc Degeneration.
Oxidative medicine and cellular longevity
Zheng HL,Xu WN,Chen PB,Jiang LS,Zheng XF,Jiang SD
Tue Apr 26 00:00:00 UTC 2022
Increased Expression of Prolyl Endopeptidase Induced by Oxidative Stress in Nucleus Pulposus Cells Aggravates Intervertebral Disc Degeneration.
Oxidative medicine and cellular longevity
Zheng HL,Xu WN,Chen PB,Jiang LS,Zheng XF,Jiang SD
Tue Apr 26 00:00:00 UTC 2022
Increased Expression of Prolyl Endopeptidase Induced by Oxidative Stress in Nucleus Pulposus Cells Aggravates Intervertebral Disc Degeneration.
Oxidative medicine and cellular longevity
Zheng HL,Xu WN,Chen PB,Jiang LS,Zheng XF,Jiang SD
Tue Apr 26 00:00:00 UTC 2022
Increased Expression of Prolyl Endopeptidase Induced by Oxidative Stress in Nucleus Pulposus Cells Aggravates Intervertebral Disc Degeneration.
Oxidative medicine and cellular longevity
Zheng HL,Xu WN,Chen PB,Jiang LS,Zheng XF,Jiang SD
Tue Apr 26 00:00:00 UTC 2022
HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3.
Experimental & molecular medicine
Hu B,Wang P,Zhang S,Liu W,Lv X,Shi D,Zhao L,Liu H,Wang B,Chen S,Shao Z
Tue Mar 01 00:00:00 UTC 2022
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Shen Y,Fan X,Qu Y,Tang M,Huang Y,Peng Y,Fu Q
Thu Sep 01 00:00:00 UTC 2022
Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.
Cellular signalling
Dai WY,Luo ZP
Tue Mar 01 00:00:00 UTC 2022
Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.
Cellular signalling
Dai WY,Luo ZP
Tue Mar 01 00:00:00 UTC 2022
Anti-photoaging effects of flexible nanoliposomes encapsulated Moringa oleifera Lam. isothiocyanate in UVB-induced cell damage in HaCaT cells.
Drug delivery
Wang Y,Ouyang Q,Chang X,Yang M,He J,Tian Y,Sheng J
Thu Dec 01 00:00:00 UTC 2022
Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling.
Acta pharmaceutica Sinica. B
Sun Z,Liu Q,Lv Z,Li J,Xu X,Sun H,Wang M,Sun K,Shi T,Liu Z,Tan G,Yan W,Wu R,Yang YX,Ikegawa S,Jiang Q,Sun Y,Shi D
Fri Jul 01 00:00:00 UTC 2022
Effects of intra-articular inoculation with Mycoplasma bovis on immunological responses in calf joints.
Veterinary immunology and immunopathology
Nishi K,Hirano Y,Sato A,Eguchi A,Matsuda K,Toda M,Watanabe T,Iwasaki T,Takahashi N,Hosotani M,Watanabe R,Kato T,Ohtsuka H,Gondaira S,Higuchi H
Tue Feb 01 00:00:00 UTC 2022
Oncogenic GBX2 promotes the malignant behaviors of bladder cancer cells by binding to the ITGA5 promoter and activating its transcription.
Functional & integrative genomics
Xiong Y,Song X,Zu X,Chen M,He W,Qi L
Sat Oct 01 00:00:00 UTC 2022
Single-Cell Profiles of Age-Related Osteoarthritis Uncover Underlying Heterogeneity Associated With Disease Progression.
Frontiers in molecular biosciences
Liu W,Chen Y,Zeng G,Yang S,Yang T,Ma M,Song W
Fri Jan 28 00:00:00 UTC 2022
GBP5 drives malignancy of glioblastoma via the Src/ERK1/2/MMP3 pathway.
Cell death & disease
Yu X,Jin J,Zheng Y,Zhu H,Xu H,Ma J,Lan Q,Zhuang Z,Chen CC,Li M
Fri Feb 19 00:00:00 UTC 2021
The detrimental effect of iron on OA chondrocytes: Importance of pro-inflammatory cytokines induced iron influx and oxidative stress.
Journal of cellular and molecular medicine
Jing X,Du T,Li T,Yang X,Wang G,Liu X,Jiang Z,Cui X
Tue Jun 01 00:00:00 UTC 2021
Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.
Frontiers in pharmacology
Zhou H,Li G,Wang Y,Jiang R,Li Y,Wang H,Wang F,Ma H,Cao L
Wed Apr 28 00:00:00 UTC 2021
Staphylococcus aureus on the effect of expression of MMPs/TIMPs and uPA system in bovine mammary fibroblasts.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
Miao Z,Ding Y,Bi Y,Chen M,Cao X,Wang F
Tue Jun 01 00:00:00 UTC 2021
M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Rα2/MAPK Pathway in Rat Intervertebral Disc Degeneration.
Frontiers in immunology
Li L,Wei K,Ding Y,Ahati P,Xu H,Fang H,Wang H
Thu Oct 14 00:00:00 UTC 2021
Oroxylin A attenuates IL-1β-induced inflammatory reaction via inhibiting the activation of the ERK and PI3K/AKT signaling pathways in osteoarthritis chondrocytes.
Experimental and therapeutic medicine
Zhang Y,Weng Q,Chen J,Li M,Han J
Thu Apr 01 00:00:00 UTC 2021
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
Stem cells and development
Ding N,Zeng MY,Song WJ,Xiao CX,Li EM,Wei B
Fri Oct 15 00:00:00 UTC 2021
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Zhang Z,Wu H,Huang S,Chen L,Chen X,Zhang W,Liao L,Zhang X
Tue Jun 01 00:00:00 UTC 2021
ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-κB signaling pathway.
Biochemical and biophysical research communications
Ding W,Ge Y,Sun H,Xu J,Gu H,Bian C,Chen H,Jiang L,Yin X
Fri Apr 23 00:00:00 UTC 2021
MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagy.
Molecular medicine reports
Lan CN,Cai WJ,Shi J,Yi ZJ
Wed Dec 01 00:00:00 UTC 2021
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
Oxidative medicine and cellular longevity
Liao Z,Li S,Liu R,Feng X,Shi Y,Wang K,Li S,Zhang Y,Wu X,Yang C
Wed Dec 29 00:00:00 UTC 2021
Decursin inhibits the growth of HeLa cervical cancer cells through PI3K/Akt signaling.
Journal of Asian natural products research
Zhu ML,Li JC,Wang L,Zhong X,Zhang YW,Tan RZ,Wang HL,Fan JM,Wang L
Tue Jun 01 00:00:00 UTC 2021
Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
Osteoarthritis and cartilage
Shao Z,Wang B,Shi Y,Xie C,Huang C,Chen B,Zhang H,Zeng G,Liang H,Wu Y,Zhou Y,Tian N,Wu A,Gao W,Wang X,Zhang X
Mon Mar 01 00:00:00 UTC 2021
Chondroprotective and antiarthritic effects of galangin in osteoarthritis: An in vitro and in vivo study.
European journal of pharmacology
Huang X,Pei W,Ni B,Zhang R,You H
Sun Sep 05 00:00:00 UTC 2021
Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study.
Journal of inflammation research
Hu X,Li R,Sun M,Kong Y,Zhu H,Wang F,Wan Q
Fri Apr 22 00:00:00 UTC 2022
Ultrasmall Prussian blue nanoparticles attenuate UVA-induced cellular senescence in human dermal fibroblasts via inhibiting the ERK/AP-1 pathway.
Nanoscale
Li Y,Zeng N,Qin Z,Chen Y,Lu Q,Cheng Y,Xia Q,Lu Z,Gu N,Luo D
Fri Oct 08 00:00:00 UTC 2021
Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model.
Oxidative medicine and cellular longevity
Li BL,Liu X,Gao M,Zhang F,Chen X,He Z,Wang J,Tian W,Chen D,Zhou Z,Liu S
Thu Feb 17 00:00:00 UTC 2022
PRDM16 Inhibits Cell Proliferation and Migration via Epithelial-to-Mesenchymal Transition by Directly Targeting Pyruvate Carboxylase in Papillary Thyroid Cancer.
Frontiers in cell and developmental biology
Liu WL,Guan Q,Wen D,Ma B,Xu WB,Hu JQ,Wei WJ,Li DS,Wang Y,Xiang J,Liao T,Ji QH
Sat Nov 20 00:00:00 UTC 2021
Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats.
International immunopharmacology
Kong L,Ma Y,Wang Z,Liu N,Ma G,Liu C,Shi R,Du G
Sat May 01 00:00:00 UTC 2021
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
Bone & joint research
Liu ZM,Lu CC,Shen PC,Chou SH,Shih CL,Chen JC,Tien YC
Sun Aug 01 00:00:00 UTC 2021
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
Bone & joint research
Liu ZM,Lu CC,Shen PC,Chou SH,Shih CL,Chen JC,Tien YC
Sun Aug 01 00:00:00 UTC 2021
METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response.
Life sciences
Sang W,Xue S,Jiang Y,Lu H,Zhu L,Wang C,Ma J
Sun Aug 01 00:00:00 UTC 2021
An impaired healing model of osteochondral defect in papain-induced arthritis.
Journal of orthopaedic translation
Meng X,Grad S,Wen C,Lai Y,Alini M,Qin L,Wang X
Fri Jan 01 00:00:00 UTC 2021
Gut microbiota regulate tumor metastasis via circRNA/miRNA networks.
Gut microbes
Zhu Z,Huang J,Li X,Xing J,Chen Q,Liu R,Hua F,Qiu Z,Song Y,Bai C,Mo YY,Zhang Z
Mon Nov 09 00:00:00 UTC 2020
lncRNA HOTAIR upregulates autophagy to promote apoptosis and senescence of nucleus pulposus cells.
Journal of cellular physiology
Zhan S,Wang K,Xiang Q,Song Y,Li S,Liang H,Luo R,Wang B,Liao Z,Zhang Y,Yang C
Sun Mar 01 00:00:00 UTC 2020
The protective effect of myricitrin in osteoarthritis: An in vitro and in vivo study.
International immunopharmacology
Yan Z,Lin Z,Wu Y,Zhan J,Qi W,Lin J,Shen J,Xue X,Pan X
Wed Jul 01 00:00:00 UTC 2020
The protective effect of myricitrin in osteoarthritis: An in vitro and in vivo study.
International immunopharmacology
Yan Z,Lin Z,Wu Y,Zhan J,Qi W,Lin J,Shen J,Xue X,Pan X
Wed Jul 01 00:00:00 UTC 2020
Apatinib Inhibits the Invasion and Metastasis of Liver Cancer Cells by Downregulating MMP-Related Proteins via Regulation of the NF-κB Signaling Pathway.
BioMed research international
He X,Huang Z,Liu P,Li Q,Wang M,Qiu M,Xiong Z,Yang S
Wed Apr 28 00:00:00 UTC 2021
Stachydrine ameliorates the progression of intervertebral disc degeneration via the PI3K/Akt/NF-κB signaling pathway: in vitro and in vivo studies.
Food & function
Shao Z,Lu J,Zhang C,Zeng G,Chen B,Liang H,Wu A,Zhang X,Wang X
Tue Dec 01 00:00:00 UTC 2020
Salvianolic Acid A Has Anti-Osteoarthritis Effect In Vitro and In Vivo.
Frontiers in pharmacology
Wu Y,Wang Z,Lin Z,Fu X,Zhan J,Yu K
Mon Sep 28 00:00:00 UTC 2020
S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway.
Aging
Shao Z,Pan Z,Lin J,Zhao Q,Wang Y,Ni L,Feng S,Tian N,Wu Y,Sun L,Gao W,Zhou Y,Zhang X,Wang X
Wed Oct 07 00:00:00 UTC 2020
Neferine Inhibits Expression of Inflammatory Mediators and Matrix Degrading Enzymes in IL-1β-Treated Rat Chondrocytes via Suppressing MAPK and NF-κB Signaling Pathways.
Inflammation
Ni B,Huang X,Xi Y,Mao Z,Chu X,Zhang R,Ma X,You H
Sat Aug 01 00:00:00 UTC 2020
Inhibition of PI3K/Akt/NF-κB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies.
International immunopharmacology
Zhang C,Shao Z,Hu X,Chen Z,Li B,Jiang R,Bsoul N,Chen J,Xu C,Gao W
Tue Dec 01 00:00:00 UTC 2020
p-Coumaric Acid Attenuates IL-1β-Induced Inflammatory Responses and Cellular Senescence in Rat Chondrocytes.
Inflammation
Huang X,You Y,Xi Y,Ni B,Chu X,Zhang R,You H
Wed Apr 01 00:00:00 UTC 2020
1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis.
Aging cell
Yang R,Chen J,Zhang J,Qin R,Wang R,Qiu Y,Mao Z,Goltzman D,Miao D
Sat Feb 01 00:00:00 UTC 2020
Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.
Experimental and therapeutic medicine
Yang T,Sun W,Duan YH,Sun YB,Ren YM,Hou WY,Tian MQ
Sat Aug 01 00:00:00 UTC 2020
Mycoplasma bovis induces matrix metalloproteinase-3 expression in bovine synovial cells via up-regulation of interleukin-1β expression in mononuclear cells.
Veterinary immunology and immunopathology
Nishi K,Gondaira S,Okamoto M,Watanabe R,Hirano Y,Fujiki J,Iwano H,Higuchi H
Tue Sep 01 00:00:00 UTC 2020
Mycoplasma bovis induces matrix metalloproteinase-3 expression in bovine synovial cells via up-regulation of interleukin-1β expression in mononuclear cells.
Veterinary immunology and immunopathology
Nishi K,Gondaira S,Okamoto M,Watanabe R,Hirano Y,Fujiki J,Iwano H,Higuchi H
Tue Sep 01 00:00:00 UTC 2020
Examination of sulfonamide-based inhibitors of MMP3 using the conditioned media of invasive glioma cells.
Journal of enzyme inhibition and medicinal chemistry
Poole AT,Sitko CA,Le C,Naus CC,Hill BM,Bushnell EAC,Chen VC
Tue Dec 01 00:00:00 UTC 2020
Iron Overload Is Associated With Accelerated Progression of Osteoarthritis: The Role of DMT1 Mediated Iron Homeostasis.
Frontiers in cell and developmental biology
Jing X,Lin J,Du T,Jiang Z,Li T,Wang G,Liu X,Cui X,Sun K
Fri Jan 22 00:00:00 UTC 2021
Kadsura heteroclita stem suppresses the onset and progression of adjuvant-induced arthritis in rats.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Yu H,Zeng R,Lin Y,Li X,Tasneem S,Yang Z,Qiu YX,Li B,Wang YH,Cai X,Wang W
Wed May 01 00:00:00 UTC 2019
Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging.
Scientific reports
Ohnishi T,Yamada K,Iwasaki K,Tsujimoto T,Higashi H,Kimura T,Iwasaki N,Sudo H
Wed Dec 18 00:00:00 UTC 2019
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
Oxidative medicine and cellular longevity
Gao X,Jiang S,Du Z,Ke A,Liang Q,Li X
Mon May 04 00:00:00 UTC 2020
Intracellular iron uptake is favored in Hfe-KO mouse primary chondrocytes mimicking an osteoarthritis-related phenotype.
BioFactors (Oxford, England)
Simão M,Gavaia PJ,Camacho A,Porto G,Pinto IJ,Ea HK,Cancela ML
Mon Jul 01 00:00:00 UTC 2019
Tumor-associated macrophages (TAMs) depend on Shp2 for their anti-tumor roles in colorectal cancer.
American journal of cancer research
Wang S,Yao Y,Li H,Zheng G,Lu S,Chen W
Wed Sep 30 00:00:00 UTC 2020
Effects of simvastatin on matrix metalloproteinase regulation in IL-1β-induced SW1353 cells.
Chemico-biological interactions
Cecen B,Keles D,Oktay G,Kozaci LD
Sun Sep 01 00:00:00 UTC 2019
MiR-499a-5p suppresses apoptosis of human nucleus pulposus cells and degradation of their extracellular matrix by targeting SOX4.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Sun JC,Zheng B,Sun RX,Meng YK,Wang SM,Yang HS,Chen Y,Shi JG,Guo YF
Wed May 01 00:00:00 UTC 2019
A mechanism of regucalcin knock-down in the promotion of proliferation and movement of human cervical cancer HeLa cells.
Translational cancer research
Li X,Huang Y,Wang P,Song W,Yao Q,Hu Q,Zhou S
Mon Apr 01 00:00:00 UTC 2019
Cordycepin suppresses cell proliferation and migration by targeting CLEC2 in human gastric cancer cells via Akt signaling pathway.
Life sciences
Wang Y,Lv Y,Liu TS,Yan WD,Chen LY,Li ZH,Piao YS,An RB,Lin ZH,Ren XS
Mon Apr 15 00:00:00 UTC 2019
Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR‑384/pleiotrophin axis.
Oncology reports
Yao Y,Rao C,Zheng G,Wang S
Mon Jul 01 00:00:00 UTC 2019
Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice.
Frontiers in pharmacology
Lin Z,Wu D,Huang L,Jiang C,Pan T,Kang X,Pan J
Tue Sep 29 00:00:00 UTC 2020
25-HC promotes hepatocellular carcinoma metastasis through up-regulation of TLR4 dependent FABP4.
American journal of cancer research
Wang S,Yao Y,Wang X,Zheng G,Ouyang W,Chen W
Tue Sep 29 00:00:00 UTC 2020
Exogenous regucalcin negatively regulates the progression of cervical adenocarcinoma.
Oncology letters
Li X,Huang Y,Guo S,Xie M,Bin X,Shi M,Chen A,Chen S,Wu F,Hu Q,Zhou S
Mon Jul 01 00:00:00 UTC 2019
Cx43-Associated Secretome and Interactome Reveal Synergistic Mechanisms for Glioma Migration and MMP3 Activation.
Frontiers in neuroscience
Aftab Q,Mesnil M,Ojefua E,Poole A,Noordenbos J,Strale PO,Sitko C,Le C,Stoynov N,Foster LJ,Sin WC,Naus CC,Chen VC
Wed Sep 30 00:00:00 UTC 2020
NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway.
Journal of cellular and molecular medicine
Huang X,Ni B,Mao Z,Xi Y,Chu X,Zhang R,Ma X,You H
Fri Nov 01 00:00:00 UTC 2019
Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc.
Experimental & molecular medicine
Wu X,Liao Z,Wang K,Hua W,Liu X,Song Y,Zhang Y,Yang S,Yang C
Wed Sep 25 00:00:00 UTC 2019
Dysregulation of MiR-519d Affects Oral Squamous Cell Carcinoma Invasion and Metastasis by Targeting MMP3.
Journal of Cancer
Jin Y,Li Y,Wang X,Yang Y
Thu Oct 01 00:00:00 UTC 2020
Dysregulation of MiR-519d Affects Oral Squamous Cell Carcinoma Invasion and Metastasis by Targeting MMP3.
Journal of Cancer
Jin Y,Li Y,Wang X,Yang Y
Thu Oct 01 00:00:00 UTC 2020
Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways.
International immunopharmacology
Wu Y,Lin Z,Yan Z,Wang Z,Fu X,Yu K
Tue Oct 01 00:00:00 UTC 2019
Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer.
Carcinogenesis
Li H,Tong X,Xu Y,Wang M,Dai H,Shi T,Sun M,Chen K,Cheng X,Wei Q
Wed Oct 16 00:00:00 UTC 2019
Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway.
Cell proliferation
Wang Y,He G,Tang H,Shi Y,Kang X,Lyu J,Zhu M,Zhou M,Yang M,Mu M,Chen W,Zhou B,Zhang J,Tang K
Mon Jul 01 00:00:00 UTC 2019
Development of a Mouse Model of Knee Osteoarthritis Based on Obesity and Bipedal Walking.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Son KM,Jung HA,Hong JI,Park IY,Kim HA
Fri Nov 01 00:00:00 UTC 2019
miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4.
Bone
Xue H,Tu Y,Ma T,Wen T,Yang T,Xue L,Cai M,Wang F,Guan M
Sat Jun 01 00:00:00 UTC 2019
25-HC decreases the sensitivity of human gastric cancer cells to 5-fluorouracil and promotes cells invasion via the TLR2/NF-κB signaling pathway.
International journal of oncology
Wang S,Yao Y,Rao C,Zheng G,Chen W
Fri Mar 01 00:00:00 UTC 2019
Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.
International immunopharmacology
Ding QH,Ye CY,Chen EM,Zhang W,Wang XH
Wed Aug 01 00:00:00 UTC 2018
Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.
International immunopharmacology
Ding QH,Ye CY,Chen EM,Zhang W,Wang XH
Wed Aug 01 00:00:00 UTC 2018
mTOR-mediated inactivation of 4E-BP1, an inhibitor of translation, precedes cartilage degeneration in rat osteoarthritic knees.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Katsara O,Kolupaeva V
Mon Oct 01 00:00:00 UTC 2018
mTOR-mediated inactivation of 4E-BP1, an inhibitor of translation, precedes cartilage degeneration in rat osteoarthritic knees.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Katsara O,Kolupaeva V
Mon Oct 01 00:00:00 UTC 2018
Tumor cell density regulates matrix metalloproteinases for enhanced migration.
Oncotarget
Jayatilaka H,Umanzor FG,Shah V,Meirson T,Russo G,Starich B,Tyle P,Lee JSH,Khatau S,Gil-Henn H,Wirtz D
Fri Aug 24 00:00:00 UTC 2018
Tumor cell density regulates matrix metalloproteinases for enhanced migration.
Oncotarget
Jayatilaka H,Umanzor FG,Shah V,Meirson T,Russo G,Starich B,Tyle P,Lee JSH,Khatau S,Gil-Henn H,Wirtz D
Fri Aug 24 00:00:00 UTC 2018
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
Frontiers in pharmacology
Liang S,Lv ZT,Zhang JM,Wang YT,Dong YH,Wang ZG,Chen K,Cheng P,Yang Q,Guo FJ,Lu WW,Zhu WT,Chen AM
Tue Sep 29 00:00:00 UTC 2020
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
Frontiers in pharmacology
Liang S,Lv ZT,Zhang JM,Wang YT,Dong YH,Wang ZG,Chen K,Cheng P,Yang Q,Guo FJ,Lu WW,Zhu WT,Chen AM
Tue Sep 29 00:00:00 UTC 2020
Icariin inhibits MMP‑1, MMP‑3 and MMP‑13 expression through MAPK pathways in IL‑1β‑stimulated SW1353 chondrosarcoma cells.
Molecular medicine reports
Zeng L,Rong XF,Li RH,Wu XY
Mon May 01 00:00:00 UTC 2017
Icariin inhibits MMP‑1, MMP‑3 and MMP‑13 expression through MAPK pathways in IL‑1β‑stimulated SW1353 chondrosarcoma cells.
Molecular medicine reports
Zeng L,Rong XF,Li RH,Wu XY
Mon May 01 00:00:00 UTC 2017
Ethanol Extract of Root of Prunus persica Inhibited the Growth of Liver Cancer Cell HepG2 by Inducing Cell Cycle Arrest and Migration Suppression.
Evidence-based complementary and alternative medicine : eCAM
Shen H,Wang H,Wang L,Wang L,Zhu M,Ming Y,Zhao S,Fan J,Lai EY
Thu Oct 01 00:00:00 UTC 2020
Ethanol Extract of Root of Prunus persica Inhibited the Growth of Liver Cancer Cell HepG2 by Inducing Cell Cycle Arrest and Migration Suppression.
Evidence-based complementary and alternative medicine : eCAM
Shen H,Wang H,Wang L,Wang L,Zhu M,Ming Y,Zhao S,Fan J,Lai EY
Thu Oct 01 00:00:00 UTC 2020
Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model.
Evidence-based complementary and alternative medicine : eCAM
Zeng L,Xiao CZ,Deng ZT,Li RH
Thu Oct 01 00:00:00 UTC 2020
Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model.
Evidence-based complementary and alternative medicine : eCAM
Zeng L,Xiao CZ,Deng ZT,Li RH
Thu Oct 01 00:00:00 UTC 2020
Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells.
Oncotarget
Wang J,Wu Y,Guo J,Fei X,Yu L,Ma S
Tue Oct 10 00:00:00 UTC 2017
Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells.
Oncotarget
Wang J,Wu Y,Guo J,Fei X,Yu L,Ma S
Tue Oct 10 00:00:00 UTC 2017
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Inflammation
Tu J,Li W,Zhang Y,Wu X,Song Y,Kang L,Liu W,Wang K,Li S,Hua W,Yang C
Thu Jun 01 00:00:00 UTC 2017
18 β-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration.
International journal of oncology
Wang S,Shen Y,Qiu R,Chen Z,Chen Z,Chen W
Tue Aug 01 00:00:00 UTC 2017
Transcriptome analysis in primary colorectal cancer tissues from patients with and without liver metastases using next-generation sequencing.
Cancer medicine
Wang S,Zhang C,Zhang Z,Qian W,Sun Y,Ji B,Zhang Y,Zhu C,Ji D,Wang Q,Sun Y
Tue Aug 01 00:00:00 UTC 2017
Transcriptome analysis in primary colorectal cancer tissues from patients with and without liver metastases using next-generation sequencing.
Cancer medicine
Wang S,Zhang C,Zhang Z,Qian W,Sun Y,Ji B,Zhang Y,Zhu C,Ji D,Wang Q,Sun Y
Tue Aug 01 00:00:00 UTC 2017
AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.
Scientific reports
Zhou S,Lu W,Chen L,Ge Q,Chen D,Xu Z,Shi D,Dai J,Li J,Ju H,Cao Y,Qin J,Chen S,Teng H,Jiang Q
Wed Feb 22 00:00:00 UTC 2017
AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.
Scientific reports
Zhou S,Lu W,Chen L,Ge Q,Chen D,Xu Z,Shi D,Dai J,Li J,Ju H,Cao Y,Qin J,Chen S,Teng H,Jiang Q
Wed Feb 22 00:00:00 UTC 2017
Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling.
Scientific reports
Wang L,Hu L,Zhou X,Xiong Z,Zhang C,Shehada HMA,Hu B,Song J,Chen L
Tue Oct 17 00:00:00 UTC 2017
Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling.
Scientific reports
Wang L,Hu L,Zhou X,Xiong Z,Zhang C,Shehada HMA,Hu B,Song J,Chen L
Tue Oct 17 00:00:00 UTC 2017
Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions.
BMC musculoskeletal disorders
Nakamura DS,Hollander JM,Uchimura T,Nielsen HC,Zeng L
Wed Jan 25 00:00:00 UTC 2017
Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions.
BMC musculoskeletal disorders
Nakamura DS,Hollander JM,Uchimura T,Nielsen HC,Zeng L
Wed Jan 25 00:00:00 UTC 2017
Linc-DYNC2H1-4 promotes EMT and CSC phenotypes by acting as a sponge of miR-145 in pancreatic cancer cells.
Cell death & disease
Gao Y,Zhang Z,Li K,Gong L,Yang Q,Huang X,Hong C,Ding M,Yang H
Thu Jul 13 00:00:00 UTC 2017
Linc-DYNC2H1-4 promotes EMT and CSC phenotypes by acting as a sponge of miR-145 in pancreatic cancer cells.
Cell death & disease
Gao Y,Zhang Z,Li K,Gong L,Yang Q,Huang X,Hong C,Ding M,Yang H
Thu Jul 13 00:00:00 UTC 2017
DIXDC1 activates the Wnt signaling pathway and promotes gastric cancer cell invasion and metastasis.
Molecular carcinogenesis
Tan C,Qiao F,Wei P,Chi Y,Wang W,Ni S,Wang Q,Chen T,Sheng W,Du X,Wang L
Fri Apr 01 00:00:00 UTC 2016
DIXDC1 activates the Wnt signaling pathway and promotes gastric cancer cell invasion and metastasis.
Molecular carcinogenesis
Tan C,Qiao F,Wei P,Chi Y,Wang W,Ni S,Wang Q,Chen T,Sheng W,Du X,Wang L
Fri Apr 01 00:00:00 UTC 2016
Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease.
Molecular medicine reports
Qu H,Li J,Wu LD,Chen WP
Thu Sep 01 00:00:00 UTC 2016
Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease.
Molecular medicine reports
Qu H,Li J,Wu LD,Chen WP
Thu Sep 01 00:00:00 UTC 2016
A comparison of incidences of bladder neck contracture of 80- versus 180-W GreenLight laser photoselective vaporization of benign prostatic hyperplasia.
Lasers in medical science
Hu B,Song Z,Liu H,Qiao L,Zhao Y,Wang M,Song W,Zhang D,Jin X,Zhang H
Tue Nov 01 00:00:00 UTC 2016
A comparison of incidences of bladder neck contracture of 80- versus 180-W GreenLight laser photoselective vaporization of benign prostatic hyperplasia.
Lasers in medical science
Hu B,Song Z,Liu H,Qiao L,Zhao Y,Wang M,Song W,Zhang D,Jin X,Zhang H
Tue Nov 01 00:00:00 UTC 2016
A comparison of incidences of bladder neck contracture of 80- versus 180-W GreenLight laser photoselective vaporization of benign prostatic hyperplasia.
Lasers in medical science
Hu B,Song Z,Liu H,Qiao L,Zhao Y,Wang M,Song W,Zhang D,Jin X,Zhang H
Tue Nov 01 00:00:00 UTC 2016
A comparison of incidences of bladder neck contracture of 80- versus 180-W GreenLight laser photoselective vaporization of benign prostatic hyperplasia.
Lasers in medical science
Hu B,Song Z,Liu H,Qiao L,Zhao Y,Wang M,Song W,Zhang D,Jin X,Zhang H
Tue Nov 01 00:00:00 UTC 2016
Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress.
Osteoarthritis and cartilage
Camacho A,Simão M,Ea HK,Cohen-Solal M,Richette P,Branco J,Cancela ML
Tue Mar 01 00:00:00 UTC 2016
BATF2 Deficiency Promotes Progression in Human Colorectal Cancer via Activation of HGF/MET Signaling: A Potential Rationale for Combining MET Inhibitors with IFNs.
Clinical cancer research : an official journal of the American Association for Cancer Research
Liu Z,Wei P,Yang Y,Cui W,Cao B,Tan C,Yu B,Bi R,Xia K,Chen W,Wang Y,Zhang Y,Du X,Zhou X
Wed Apr 01 00:00:00 UTC 2015
BATF2 Deficiency Promotes Progression in Human Colorectal Cancer via Activation of HGF/MET Signaling: A Potential Rationale for Combining MET Inhibitors with IFNs.
Clinical cancer research : an official journal of the American Association for Cancer Research
Liu Z,Wei P,Yang Y,Cui W,Cao B,Tan C,Yu B,Bi R,Xia K,Chen W,Wang Y,Zhang Y,Du X,Zhou X
Wed Apr 01 00:00:00 UTC 2015
17β-estradiol protects against apoptosis induced by interleukin-1β in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13.
Apoptosis : an international journal on programmed cell death
Yang SD,Yang DL,Sun YP,Wang BL,Ma L,Feng SQ,Ding WY
Sun Mar 01 00:00:00 UTC 2015
17β-estradiol protects against apoptosis induced by interleukin-1β in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13.
Apoptosis : an international journal on programmed cell death
Yang SD,Yang DL,Sun YP,Wang BL,Ma L,Feng SQ,Ding WY
Sun Mar 01 00:00:00 UTC 2015
Tumor cell expression of MMP3 as a prognostic factor for poor survival in pancreatic, pulmonary, and mammary carcinoma.
Genes & cancer
Mehner C,Miller E,Nassar A,Bamlet WR,Radisky ES,Radisky DC
Sun Nov 01 00:00:00 UTC 2015
Tumor cell expression of MMP3 as a prognostic factor for poor survival in pancreatic, pulmonary, and mammary carcinoma.
Genes & cancer
Mehner C,Miller E,Nassar A,Bamlet WR,Radisky ES,Radisky DC
Sun Nov 01 00:00:00 UTC 2015
Enriched CD44(+)/CD24(-) population drives the aggressive phenotypes presented in triple-negative breast cancer (TNBC).
Cancer letters
Ma F,Li H,Wang H,Shi X,Fan Y,Ding X,Lin C,Zhan Q,Qian H,Xu B
Tue Oct 28 00:00:00 UTC 2014
Enriched CD44(+)/CD24(-) population drives the aggressive phenotypes presented in triple-negative breast cancer (TNBC).
Cancer letters
Ma F,Li H,Wang H,Shi X,Fan Y,Ding X,Lin C,Zhan Q,Qian H,Xu B
Tue Oct 28 00:00:00 UTC 2014
Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma.
Molecular cancer research : MCR
Mehner C,Miller E,Khauv D,Nassar A,Oberg AL,Bamlet WR,Zhang L,Waldmann J,Radisky ES,Crawford HC,Radisky DC
Wed Oct 01 00:00:00 UTC 2014
Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma.
Molecular cancer research : MCR
Mehner C,Miller E,Khauv D,Nassar A,Oberg AL,Bamlet WR,Zhang L,Waldmann J,Radisky ES,Crawford HC,Radisky DC
Wed Oct 01 00:00:00 UTC 2014
Hinokitiol reduces matrix metalloproteinase expression by inhibiting Wnt/β-Catenin signaling in vitro and in vivo.
International immunopharmacology
Li J,Zhou XD,Yang KH,Fan TD,Chen WP,Jiang LF,Bao JP,Wu LD,Xiong Y
Sat Nov 01 00:00:00 UTC 2014
Hinokitiol reduces matrix metalloproteinase expression by inhibiting Wnt/β-Catenin signaling in vitro and in vivo.
International immunopharmacology
Li J,Zhou XD,Yang KH,Fan TD,Chen WP,Jiang LF,Bao JP,Wu LD,Xiong Y
Sat Nov 01 00:00:00 UTC 2014
Rho GDP dissociation inhibitor beta promotes cell proliferation and invasion by modulating the AKT pathway in hepatocellular carcinoma.
DNA and cell biology
Fang Y,Yi J,Lizhi L,Qiucheng C
Sat Nov 01 00:00:00 UTC 2014
Rho GDP dissociation inhibitor beta promotes cell proliferation and invasion by modulating the AKT pathway in hepatocellular carcinoma.
DNA and cell biology
Fang Y,Yi J,Lizhi L,Qiucheng C
Sat Nov 01 00:00:00 UTC 2014
Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies.
BMC complementary and alternative medicine
Wu DQ,Zhong HM,Ding QH,Ba L
Sat Nov 15 00:00:00 UTC 2014
Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies.
BMC complementary and alternative medicine
Wu DQ,Zhong HM,Ding QH,Ba L
Sat Nov 15 00:00:00 UTC 2014
Matrix metalloproteinase 3 promotes cellular anti-dengue virus response via interaction with transcription factor NFκB in cell nucleus.
PloS one
Zuo X,Pan W,Feng T,Shi X,Dai J
Wed Sep 10 00:00:00 UTC 2014
Matrix metalloproteinase 3 promotes cellular anti-dengue virus response via interaction with transcription factor NFκB in cell nucleus.
PloS one
Zuo X,Pan W,Feng T,Shi X,Dai J
Wed Sep 10 00:00:00 UTC 2014
Anti-arthritic effects of crocin in interleukin-1β-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Ding Q,Zhong H,Qi Y,Cheng Y,Li W,Yan S,Wang X
Tue Jan 01 00:00:00 UTC 2013
Anti-arthritic effects of crocin in interleukin-1β-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Ding Q,Zhong H,Qi Y,Cheng Y,Li W,Yan S,Wang X
Tue Jan 01 00:00:00 UTC 2013
CD133 affects the invasive ability of HCT116 cells by regulating TIMP-2.
The American journal of pathology
Zhang M,Liu Y,Feng H,Bian X,Zhao W,Yang Z,Gu B,Li Z,Liu Y
Fri Feb 01 00:00:00 UTC 2013
CD133 affects the invasive ability of HCT116 cells by regulating TIMP-2.
The American journal of pathology
Zhang M,Liu Y,Feng H,Bian X,Zhao W,Yang Z,Gu B,Li Z,Liu Y
Fri Feb 01 00:00:00 UTC 2013
Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes.
European journal of pharmacology
Ding QH,Cheng Y,Chen WP,Zhong HM,Wang XH
Wed May 15 00:00:00 UTC 2013
Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes.
European journal of pharmacology
Ding QH,Cheng Y,Chen WP,Zhong HM,Wang XH
Wed May 15 00:00:00 UTC 2013
Substance P enhances collagen remodeling and MMP-3 expression by human tenocytes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Fong G,Backman LJ,Hart DA,Danielson P,McCormack B,Scott A
Tue Jan 01 00:00:00 UTC 2013
Substance P enhances collagen remodeling and MMP-3 expression by human tenocytes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Fong G,Backman LJ,Hart DA,Danielson P,McCormack B,Scott A
Tue Jan 01 00:00:00 UTC 2013
Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts.
Arthritis and rheumatism
Yoshioka Y,Kozawa E,Urakawa H,Arai E,Futamura N,Zhuo L,Kimata K,Ishiguro N,Nishida Y
Wed May 01 00:00:00 UTC 2013
Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts.
Arthritis and rheumatism
Yoshioka Y,Kozawa E,Urakawa H,Arai E,Futamura N,Zhuo L,Kimata K,Ishiguro N,Nishida Y
Wed May 01 00:00:00 UTC 2013
Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts.
Arthritis and rheumatism
Yoshioka Y,Kozawa E,Urakawa H,Arai E,Futamura N,Zhuo L,Kimata K,Ishiguro N,Nishida Y
Wed May 01 00:00:00 UTC 2013
Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts.
Arthritis and rheumatism
Yoshioka Y,Kozawa E,Urakawa H,Arai E,Futamura N,Zhuo L,Kimata K,Ishiguro N,Nishida Y
Wed May 01 00:00:00 UTC 2013
