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Proteintech
MMP3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
17873-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MMP3 Fusion Protein Ag12359 (26-477 aa encoded by BC074869)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GEDTSMNLV QKYLENYYDL EKDVKQFVRR KDSGPVVKKI REMQKFLGLE VTGKLDSDTL EVMRKPRCGV PDVGHFRTFP GIPKWRKTHL TYRIVNYTPD LPKDAVDSAV EKALKVWEEV TPLTFSRLYE GEADIMISFA VREHGDFYPF DGPGNVLAHA YAPGPGINGD AHFDDDEQWT KDTTGTNLFL VAAHEIGHSL GLFHSANTEA LMYPLYHSLT DLTRFRLSQD DINGIQSLYG PPPDSPETPL VPTEPVPPEP GTPANCDPAL SFDAVSTLRG EILIFKDRHF WRKSLRKLEP ELHLISSFWP SLPSGVDAAY EVTSKDLVFI FKGNQFWAIR GNEVRAGYPR GIHTLGFPPT VRKIDAAISD KEKNKTYFFV EDKYWRFDEK RNSMEPGFPK QIAEDFPGID SKIDAVFEEF GFFYFFTGSS QLEFDPNAKK VTHTLKSNSW LNC (26-477 aa encoded by BC074869)
Target Information
MMP3 (stromelysin-1) belongs to the peptidase M10A subfamily. It is secreted in its pro-protein form, and is activated by extracellular proteinase cleavage. MMP3 is capable of binding to zinc and calcium ions, and has metallo-endopeptidase activity. The active enzyme degrades collagen, gelatin, fibronectin, and laminin. It is involved in normal cellular processes such as wound repair and tissue remodeling. Mutations in the gene can result in coronary heart disease 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 3.4.24.17; matrix metallo protease; matrix metalloproteinase 3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); matrix metalloproteinase-3; MMP; MMPs; progelatinase; proteoglycanase; PTR1 protein; Stromelysin1; transin-1; Transin1; unnamed protein product
Gene Aliases: CHDS6; EMS-2; MMP-3; SL-1; SLN-1; SLN1; STMY; STMY1; STR-1; STR1
UniProt ID: (Human) P08254, (Mouse) P28862
Entrez Gene ID: (Human) 4314, (Mouse) 17392, (Rat) 171045
proteolysis
protein catabolic process
extracellular matrix organization
regulation of cell migration
positive regulation of cell migration
collagen catabolic process
positive regulation of protein complex assembly
cellular response to reactive oxygen species
negative regulation of protein kinase B signaling
cellular response to amino acid stimulus
cellular response to UV-A
negative regulation of reactive oxygen species metabolic process
response to hypoxia
female pregnancy
response to mechanical stimulus
response to estradiol
response to lipopolysaccharide
response to cytokine
response to tumor necrosis factor
response to amino acid
response to interleukin-1
cellular response to interleukin-1
cellular response to cell-matrix adhesion
extracellular matrix disassembly
cellular response to lipopolysaccharide
cellular response to nitric oxide
regulation of neuroinflammatory response
response to amyloid-beta
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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