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MMP3 Polyclonal Antibody

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MMP3 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of A549 cells using 17873-1-AP (MMP3 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

MMP3 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human stomach cancer using 17873-1-AP (MMP3 antibody) at dilution of 1:50 (under 40x lens).

MMP3 Antibody in Western Blot (WB) — Human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 17873-1-AP (MMP3 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

Product Details

17873-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2400	View 20 publications 20 publications
Immunohistochemistry (IHC)	-	View 8 publications 8 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunocytochemistry (ICC/IF)	1:20-1:200	-
Miscellaneous PubMed (Misc)	-	View 2 publications 2 publications

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse, Rabbit, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	MMP3 Fusion Protein Ag12359 (26-477 aa encoded by BC074869) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.2 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: GEDTSMNLV QKYLENYYDL EKDVKQFVRR KDSGPVVKKI REMQKFLGLE VTGKLDSDTL EVMRKPRCGV PDVGHFRTFP GIPKWRKTHL TYRIVNYTPD LPKDAVDSAV EKALKVWEEV TPLTFSRLYE GEADIMISFA VREHGDFYPF DGPGNVLAHA YAPGPGINGD AHFDDDEQWT KDTTGTNLFL VAAHEIGHSL GLFHSANTEA LMYPLYHSLT DLTRFRLSQD DINGIQSLYG PPPDSPETPL VPTEPVPPEP GTPANCDPAL SFDAVSTLRG EILIFKDRHF WRKSLRKLEP ELHLISSFWP SLPSGVDAAY EVTSKDLVFI FKGNQFWAIR GNEVRAGYPR GIHTLGFPPT VRKIDAAISD KEKNKTYFFV EDKYWRFDEK RNSMEPGFPK QIAEDFPGID SKIDAVFEEF GFFYFFTGSS QLEFDPNAKK VTHTLKSNSW LNC (26-477 aa encoded by BC074869)

Target Information

MMP3 (stromelysin-1) belongs to the peptidase M10A subfamily. It is secreted in its pro-protein form, and is activated by extracellular proteinase cleavage. MMP3 is capable of binding to zinc and calcium ions, and has metallo-endopeptidase activity. The active enzyme degrades collagen, gelatin, fibronectin, and laminin. It is involved in normal cellular processes such as wound repair and tissue remodeling. Mutations in the gene can result in coronary heart disease 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EC 3.4.24.17; EMS-2; matrix metallo protease; matrix metalloproteinase 3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); Matrix metalloproteinase-3; MMP; MMP-3; MMPs; progelatinase; proteoglycanase; SL-1; stromelysin 1; Stromelysin-1; Stromelysin1; Transin-1; Transin1

Gene Aliases: CHDS6; MMP-3; MMP3; SL-1; SLN-1; SLN1; STMY; STMY1; STR-1; STR1

UniProt ID: (Human) P08254, (Mouse) P28862

Entrez Gene ID: (Human) 4314, (Mouse) 17392, (Rat) 171045

Molecular Function: metalloprotease