Immunogen sequence: ALVGDEVELP CRISPGKNAT GMEVGWYRPP FSRVVHLYRN GKDQDGDQAP EYRGRTELLK DAIGEGKVTL RIRNVRFSDE GGFTCFFRDH SYQEEAAMEL KVEDPFYWVS PG
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 89%.
Binds to an epitope located within the peptide sequence GMEVGWYRPP as determined by overlapping synthetic peptides.
Myelin / Oligodendrocyte Specific Protein (MOSP) (pI of ~6.7) is found exclusively on oligodendrocytes and myelin in the central nervous system (CNS). Myelin is produced by oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system (PNS). Defining the differences between CNS and PNS myelin may provide insights into the process of myelination and the pathogenesis of certain idiopathic diseases involving myelin such as multiple sclerosis, certain leukodystrophies, and other myelinopathies. On demyelination, immunoreactivity for MOSP, like MBP, is lost.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DAQB-92E24.2; dystonia 2, torsion (autosomal recessive); MGC26137; MOG; MOG alpha-5; MOG alpha-6; MOG AluA; MOG AluB; MOG Ig-AluB; MOGIG-2; myelin oligodendrocyte glycoprotein; Myelin-oligodendrocyte glycoprotein
Gene Aliases: B230317G11Rik; BTN6; BTNL11; MOG; MOGIG2; NRCLP7