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Proteintech
MPP5 Polyclonal Antibody
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Product Details
17710-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MPP5 Fusion Protein Ag12010 (1-341 aa encoded by BC095485)
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTTSHMNGH VTEESDSEVK NVDLASPEEH QKHREMAVDC PGDLGTRMMP IRRSAQLERI RQQQEDMRRR REEEGKKQEL DLNSSMRLKK LAQIPPKTGI DNPMFDTEEG IVLESPHYAV KILEIEDLFS SLKHIQHTLV DSQSQEDISL LLQLVQNKDF QNAFKIHNAI TVHMNKASPP FPLISNAQDL AQEVQTVLKP VHHKEGQELT ALLNTPHIQA LLLAHDKVAE QEMQLEPITD ERVYESIGQY GGETVKIVRI EKARDIPLGA TVRNEMDSVI ISRIVKGGAA EKSGLLHEGD EVLEINGIEI RGKDVNEVFD LLSDMHGTLT FVLIPSQQIK PP (1-341 aa encoded by BC095485)
Target Information
MPP5 (Membrane Protein, Palmitoylated 5) plays a critical role in neurogenesis and hematopoiesis. This protein is crucial for establishing and maintaining cell polarity in epithelial cells and neurons. It is involved in the Par-3 complex, which contributes to maintaining tight junctions in epithelial cells. Mutations in MPP5 have been associated with severe neurologic impairments, including global developmental delay (GDD) and behavioral changes. In animal models, MPP5 is highly involved in the early differentiation of multipotent progenitors and supports long-term lineage-specific contributions, primarily in myeloid and lymphoid cells. MPP5 variants disrupt normal cellular function, leading to profound developmental and functional abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ12615; MAGUK p55 subfamily member 5; membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 5); Membrane protein, palmitoylated 5; membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); palmitoylated 5; protein associated with lin seven 1; Protein associated with Lin-7 1; Protein PALS1; stardust
Gene Aliases: 3830420B02Rik; AI255216; AI644496; MPP5; PALS1
UniProt ID: (Human) Q8N3R9, (Mouse) Q9JLB2, (Rat) B4F7E7
Entrez Gene ID: (Human) 64398, (Mouse) 56217, (Rat) 314259
morphogenesis of an epithelial sheet
peripheral nervous system myelin maintenance
myelin assembly
protein localization to myelin sheath abaxonal region
bicellular tight junction assembly
establishment of protein localization to plasma membrane
establishment of epithelial cell polarity
plasma membrane organization
nucleotide phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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