Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: M-RIP; Myosin phosphatase Rho-interacting protein; myosin phosphatase-Rho interacting protein; p116 Rho interacting protein; p116Rip; Rho interacting protein 3; Rho-interacting protein 3; Rho-interacting protein 3 (p116RIP) (RIP3); RIP3
Gene Aliases: 9530046C02; AA536749; AI647711; C76423; KIAA0864; M-RIP; mKIAA0864; MPRIP; MRIP; p116Rip; RHOIP3; RIP3
Molecular Function: actin or actin-binding cytoskeletal protein