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Invitrogen
MRP1 Polyclonal Antibody
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Product Details
PA5-78694
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human MRP1 (1514-1531aa, LLQQRGLFYSMAKDAGLV).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: JURKAT Cell, CEM Cell, A549 Cell. IHC: Human Lung Cancer Tissue.
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-binding cassette sub-family C ( CFTR/MRP) member 1a; ATP-binding cassette sub-family C member 1; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex13&14; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex25&26; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1a; ATP-binding cassette, sub-family C (CFTR/MRP), member 1b; DKFZp686N04233; DKFZp781G125; Glutathione-S-conjugate-translocating ATPase ABCC1; leuk; Leukotriene C(4) transporter; LTC4 transporter; multidrug resistance protein 1; Multidrug resistance-associated protein 1; multiple drug resistance-associated protein
Gene Aliases: ABC29; ABCC; ABCC1; Abcc1a; Abcc1b; Avcc1a; GS-X; Mdrap; MRP; MRP1
UniProt ID: (Human) P33527, (Rat) Q8CG09, (Mouse) O35379
Entrez Gene ID: (Human) 4363, (Rat) 24565, (Mouse) 17250
transporter activity
ATP binding
cobalamin-transporting ATPase activity
ATPase activity
ATPase activity, coupled to transmembrane movement of substances
anion transmembrane-transporting ATPase activity
long-chain fatty acid transporter activity
xenobiotic-transporting ATPase activity
drug transmembrane transporter activity
glutathione S-conjugate-exporting ATPase activity
efflux transmembrane transporter activity
oxidoreductase activity
lipid-transporting ATPase activity
glutathione transmembrane transporter activity
sphingolipid transporter activity
nucleotide binding
hydrolase activity
ATP-binding cassette (ABC) transporter
leukotriene metabolic process
transport
cobalamin metabolic process
cobalamin transport
vitamin transmembrane transport
response to drug
transmembrane transport
anion transmembrane transport
drug transmembrane transport
response to oxidative stress
plasma membrane long-chain fatty acid transport
positive regulation of cell migration
phospholipid efflux
glutathione transmembrane transport
xenobiotic transport
daunorubicin transport
drug export
oxidation-reduction process
cell chemotaxis
negative regulation of neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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