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Invitrogen
MRVI1 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 3
MRVI1 Antibody (PA3-851) in ICC/IF
Immunofluorescence analysis of MRVI1 (IRAG) was performed using 70% confluent log phase Neuro-2a cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with MRVI1 Rabbit polyclonal antibody (Product # PA3-851) at 5 µg/mL in 0.1% BSA, incubated overnight at 4 degree Celsius and then labeled with Goat anti-Rabbit IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A270... View More
Product Details
PA3-851
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues 93-107 of bovine IRAG.
Conjugate
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2170655
Product Specific Information
PA3-851 detects CARP from mouse and bovine samples.
PA3-851 has been successfully used in Western blot and immunocytochemistry procedures.
The PA3-851 immunogen is a synthetic peptide corresponding to residues 93-107 of bovine IRAG.
Target Information
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during lymphoid differentiation. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, few of which initiate translation at a non-AUG (CUG) start site.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Inositol 1,4,5-triphosphate receptor associated 1; inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate; Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate; IP3 receptor associated cGMP kinase substrate; JAW1-related protein MRVI1; murine retrovirus integration site 1 homolog; Murine retrovirus integration site 1 protein; Protein MRVI1; retroviral integration site 1
Gene Aliases: BB115629; IRAG; Irag1; MRVI1; Ris1
UniProt ID: (Mouse) Q9WUX5
Entrez Gene ID: (Bovine) 281918, (Mouse) 17540
Molecular Function:
scaffold/adaptor protein
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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