This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
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PA3-851 detects CARP from mouse and bovine samples.
PA3-851 has been successfully used in Western blot and immunocytochemistry procedures.
The PA3-851 immunogen is a synthetic peptide corresponding to residues 93-107 of bovine IRAG.
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during lymphoid differentiation. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, few of which initiate translation at a non-AUG (CUG) start site.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Inositol 1,4,5-triphosphate receptor associated 1; inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate; Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate; IP3 receptor associated cGMP kinase substrate; JAW1-related protein MRVI1; murine retrovirus integration site 1 homolog; Murine retrovirus integration site 1 protein; Protein MRVI1; retroviral integration site 1
Gene Aliases: BB115629; IRAG; Irag1; MRVI1; Ris1
UniProt ID: (Mouse) Q9WUX5
Molecular Function: scaffold/adaptor protein