A suggested positive control for this product is tonsil tissue.
MSH2 is involved in DNA repair as a mismatch repair protein, and mutations of MSH2 are found in approximately 50% of inherited non polyposis colorectal carcinoma. Defects in MSH2 are a cause of hereditary non-polyposis colorectal cancer (HNPCC) (Lynch syndrome). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. it is characterized by a familial predisposition to early onset colorectal carcinoma (crc) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world.
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Protein Aliases: COCA1; DNA mismatch repair protein Msh2; FCC1; hMSH2; HNPCC; HNPCC1; mutS homolog 2, colon cancer, nonpolyposis type 1; MutS protein homolog 2
Gene Aliases: COCA1; FCC1; HNPCC; HNPCC1; LCFS2; MSH2
UniProt ID: (Human) P43246
Entrez Gene ID: (Human) 4436