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Invitrogen
MSH3 Polyclonal Antibody
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Product Details
PA5-75306
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 50-100 of Human MSH3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Divergent upstream protein; DNA mismatch repair protein Msh3; DUP; hMSH3; Mismatch repair protein 1; MRP1; Protein repair-1; Protein repair-3; REP-1; REP-3
Gene Aliases: D13Em1; DUC1; DUG; DUP; MRP1; MSH3; Rep-3; Rep3
UniProt ID: (Human) P20585, (Mouse) P13705
Entrez Gene ID: (Human) 4437, (Rat) 499505, (Mouse) 17686
damaged DNA binding
single-stranded DNA binding
protein binding
ATP binding
enzyme binding
mismatched DNA binding
guanine/thymine mispair binding
dinucleotide insertion or deletion binding
single guanine insertion binding
dinucleotide repeat insertion binding
oxidized purine DNA binding
protein homodimerization activity
Y-form DNA binding
heteroduplex DNA loop binding
double-strand/single-strand DNA junction binding
molecular_function
DNA binding
DNA-dependent ATPase activity
centromeric DNA binding
nucleotide binding
DNA metabolism protein
meiotic mismatch repair
DNA repair
mismatch repair
reciprocal meiotic recombination
maintenance of DNA repeat elements
negative regulation of DNA recombination
positive regulation of helicase activity
biological_process
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
cellular response to DNA damage stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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