Invitrogen

MSX2 Polyclonal Antibody

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MSX2 Antibody in Immunofluorescence (IF) — Immunofluorescence analysis of MCF-7 cells using an anti-MSX2 polyclonal antibody (Product # PA5-40367). Primary Antibody Dilution: 4 µg/mL; Secondary Antibody: Anti-rabbit Alexa 546; Secondary Antibody Dilution: 2 µg/mL.

MSX2 Antibody in Western Blot (WB) — Western blot analysis of transfected 293T cells using an anti-MSX2 polyclonal antibody (Product # PA5-40367).

Product Details

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC)

4 µg/mL

-

Immunofluorescence (IF)

4 µg/mL

-

Western Blot (WB)

0.2-1 µg/mL

-

Product Specifications

Species Reactivity

Bovine, Dog, Horse, Human, Mouse, Rabbit, Rat

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide directed towards the N-terminal of human MSX2

Conjugate

Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS with 2% sucrose

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2608897

Product Specific Information

Peptide sequence: MASPSKGNDL FSPDEEGPAV VAGPGPGPGG AEGAAEERRV KVSSLPFSVE

Sequence homology: Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 91%; Rabbit: 91%; Rat: 91%

Target Information

Msx2 is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. This protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in the Msx2 gene are associated with parietal foramina 1 and craniosynostosis type 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: homeo box, msh-like 2; Homeobox protein Hox-8; Homeobox protein Hox-8-1; Homeobox protein MSX-2; homeobox, msh-like 2; hox-8.1; msh homeo box 2; msh homeo box homolog 2; msh homeobox 1-like; msh homeobox homolog 2; muscle segmentation homologue (MSX2)

Gene Aliases: BB122635; BOS_19668; CRS2; FPP; Hox-8; Hox-8.1; HOX8; Hox8.1; MSH; Msx-2; MSX2; PFM; PFM1

UniProt ID: (Human) P35548, (Dog) Q9GK08, (Bovine) Q0P5C3, (Mouse) Q03358

Entrez Gene ID: (Rabbit) 100343959, (Human) 4488, (Dog) 403663, (Bovine) 540230, (Mouse) 17702, (Rat) 25483

Molecular Function: DNA binding protein helix-turn-helix transcription factor homeobox transcription factor nucleic acid binding transcription factor

negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation chondrocyte development osteoblast development outflow tract septum morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation endochondral bone growth transcription from RNA polymerase II promoter negative regulation of cell proliferation anterior/posterior pattern specification signal transduction involved in regulation of gene expression positive regulation of BMP signaling pathway negative regulation of CREB transcription factor activity embryonic forelimb morphogenesis embryonic hindlimb morphogenesis wound healing, spreading of epidermal cells embryonic nail plate morphogenesis negative regulation of apoptotic process negative regulation of fat cell differentiation negative regulation of keratinocyte differentiation positive regulation of osteoblast differentiation negative regulation of transcription, DNA-templated stem cell differentiation positive regulation of catagen bone trabecula formation cranial suture morphogenesis frontal suture morphogenesis branching involved in mammary gland duct morphogenesis BMP signaling pathway involved in heart development enamel mineralization cellular response to estradiol stimulus activation of meiosis negative regulation of transcription regulatory region DNA binding positive regulation of mesenchymal cell apoptotic process transcription, DNA-templated anagen cellular response to growth factor stimulus ossification outflow tract morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development embryonic limb morphogenesis BMP signaling pathway wound healing odontogenesis embryonic digit morphogenesis regulation of apoptotic process positive regulation of apoptotic process cartilage development bone morphogenesis mammary gland epithelium development

Process(es)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription cofactor activity protein binding transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding RNA polymerase II regulatory region sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, transcription factor binding DNA binding