Invitrogen

MSX2 Polyclonal Antibody

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MSX2 Antibody in Western Blot (WB) — Western blot analysis of MSX2 in whole cell lysate using 30 µg of protein. Samples were separated with 12% SDS-PAGE and incubated with MSX2 polyclonal antibody (Product # PA5-78064) using a dilution of 1:1000.

MSX2 Antibody in Western Blot (WB) — Western blot analysis of MSX2 in whole cell lysate using 30 µg of protein. Samples were separated with 12% SDS-PAGE and incubated with MSX2 polyclonal antibody (Product # PA5-78064) using a dilution of 1:1000.

MSX2 Antibody in Western Blot (WB) — Western blot analysis of MSX2 in whole cell lysate using 30 µg of protein. Samples were separated with 12% SDS-PAGE and incubated with MSX2 polyclonal antibody (Product # PA5-78064) using a dilution of 1:500.

Product Details

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3000

-

Product Specifications

Species Reactivity

Human, Mouse

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human MSX2. The exact sequence is proprietary.

Conjugate

Unconjugated

Form

Liquid

Concentration

1.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% Proclin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2736172

Product Specific Information

Positive Control: HL-60, 293T, A431, HeLa, HepG2, Neuro2A, C8D30, NIH-3T3, Raw264.7, C2C12

Predicted Reactivity: Rat (86%), Dog (86%), Rhesus Monkey (98%), Chimpanzee (100%), Bovine (94%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Msx2 is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. This protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in the Msx2 gene are associated with parietal foramina 1 and craniosynostosis type 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: homeo box, msh-like 2; Homeobox protein Hox-8; Homeobox protein Hox-8-1; Homeobox protein MSX-2; homeobox, msh-like 2; msh homeo box 2; msh homeobox homolog 2

Gene Aliases: BB122635; CRS2; FPP; Hox-8; Hox-8.1; HOX8; Hox8.1; MSH; Msx-2; MSX2; PFM; PFM1

UniProt ID: (Human) P35548, (Mouse) Q03358

Entrez Gene ID: (Human) 4488, (Mouse) 17702

Molecular Function: DNA binding protein helix-turn-helix transcription factor homeobox transcription factor nucleic acid binding transcription factor

negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation chondrocyte development osteoblast development outflow tract septum morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation endochondral bone growth transcription from RNA polymerase II promoter negative regulation of cell proliferation anterior/posterior pattern specification signal transduction involved in regulation of gene expression positive regulation of BMP signaling pathway negative regulation of CREB transcription factor activity embryonic forelimb morphogenesis embryonic hindlimb morphogenesis wound healing, spreading of epidermal cells embryonic nail plate morphogenesis negative regulation of apoptotic process negative regulation of fat cell differentiation negative regulation of keratinocyte differentiation positive regulation of osteoblast differentiation negative regulation of transcription, DNA-templated stem cell differentiation positive regulation of catagen bone trabecula formation cranial suture morphogenesis frontal suture morphogenesis branching involved in mammary gland duct morphogenesis BMP signaling pathway involved in heart development enamel mineralization cellular response to estradiol stimulus activation of meiosis negative regulation of transcription regulatory region DNA binding positive regulation of mesenchymal cell apoptotic process ossification outflow tract morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development embryonic limb morphogenesis BMP signaling pathway wound healing odontogenesis anagen embryonic digit morphogenesis regulation of apoptotic process positive regulation of apoptotic process cartilage development bone morphogenesis mammary gland epithelium development cellular response to growth factor stimulus

Process(es)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription cofactor activity protein binding transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding RNA polymerase II regulatory region sequence-specific DNA binding transcription factor activity, transcription factor binding DNA binding