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Proteintech
MTH1 Polyclonal Antibody
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Product Details
16705-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MTH1 Fusion Protein Ag10103 (19-197 aa encoded by BC014618)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSGISPQQM GEPEGSWSGK NPGTMGASRL YTLVLVLQPQ RVLLGMKKRG FGAGRWNGFG GKVQEGETIE DGARRELQEE SGLTVDALHK VGQIVFEFVG EPELMDVHVF CTDSIQGTPV ESDEMRPCWF QLDQIPFKDM WPDDSYWFPL LLQKKKFHGY FKFQGQDTIL DYTLREVDTV (19-197 aa encoded by BC014618)
Target Information
Oxygen radicals damage chromosomal DNA causing cell death and inducing mutations. Among the various classes of DNA damage caused by oxygen radicals, an oxidized form of guanine base (8-oxoguanine) appears to be important as it can pair with cytosine and adenine and G:C to T:A transversion mutation occurs. A significant amount of 8-OxoG is formed in the chromosomal DNA of mammalian cells, with most damaged nucleotides excised from the DNA and excreted in the urine. Along with 8-oxoG being present in oxidatively damaged DNA, 8-oxo-deoxyguanosine (8-oxo-dGTP) is formed in the nucleotide pool during normal cellular metabolism and following oxidative stress. The 8-oxo-dGTP nucleotide can be incorporated in DNA during polymerization and can result in a mispairing unless repaired. MTH converts 8-oxo-dGTP in the nucleotide pool to the monophosphate and prevents the misincorporation of 8-oxo-dGTP into DNA (Figure courtesy of Dr. Mark Kelley). MTH also recognizes 8-oxo-rGTP, which could incorporate into RNA during gene transcription leading to missense or nonsense protein production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2-hydroxy-dATP diphosphatase; 7,8-dihydro-8-oxoguanine triphosphatase; 8-oxo-7,8-dihydro-2'-dGTPase; 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase; 8-oxo-7,8-dihydroguanosine triphosphatase; 8-oxo-dGTPase; Methylated purine nucleoside triphosphate hydrolase; mutT human homolog (8-oxo-dGTPase); mutT human homolog 1; Nucleoside diphosphate-linked moiety X motif 1; nucleoside diphosphate-linked moiety X-type motif 1; nudix (nucleoside diphosphate linked moiety X)-type motif 1; Nudix motif 1; nudix-type motif 1; Oxidized purine nucleoside triphosphate hydrolase
Gene Aliases: MTH1; NUDT1
UniProt ID: (Human) P36639, (Rat) P53369, (Mouse) P53368
Entrez Gene ID: (Human) 4521, (Rat) 117260, (Mouse) 17766
GTPase activity
protein binding
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
snoRNA binding
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
GTP diphosphatase activity
2-hydroxy-adenosine triphosphate pyrophosphatase activity
2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity
metal ion binding
ATP diphosphatase activity
m7G(5')pppN diphosphatase activity
RNA binding
hydrolase activity
hydrolase
phosphatase
metabolite interconversion enzyme
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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