Product References
MTHFD2 suppresses glioblastoma progression via the inhibition of ERK1/2 phosphorylation.
Biochemistry and cell biology = Biochimie et biologie cellulaire
Huang M,Xue J,Chen Z,Zhou X,Chen M,Sun J,Xu Z,Wang S,Xu H,Du Z,Liu M
Wed Feb 01 00:00:00 UTC 2023
MTHFD2 suppresses glioblastoma progression via the inhibition of ERK1/2 phosphorylation.
Biochemistry and cell biology = Biochimie et biologie cellulaire
Huang M,Xue J,Chen Z,Zhou X,Chen M,Sun J,Xu Z,Wang S,Xu H,Du Z,Liu M
Wed Feb 01 00:00:00 UTC 2023
MTHFD2 reprograms macrophage polarization by inhibiting PTEN.
Cell reports
Shang M,Ni L,Shan X,Cui Y,Hu P,Ji Z,Shen L,Zhang Y,Zhou J,Wang T,Yu Q
Tue May 30 00:00:00 UTC 2023
MTHFD2 reprograms macrophage polarization by inhibiting PTEN.
Cell reports
Shang M,Ni L,Shan X,Cui Y,Hu P,Ji Z,Shen L,Zhang Y,Zhou J,Wang T,Yu Q
Tue May 30 00:00:00 UTC 2023
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion.
eLife
Mann JP,Duan X,Patel S,Tábara LC,Scurria F,Alvarez-Guaita A,Haider A,Luijten I,Page M,Protasoni M,Lim K,Virtue S,O'Rahilly S,Armstrong M,Prudent J,Semple RK,Savage DB
Wed Feb 01 00:00:00 UTC 2023
Mitochondrial folate pathway regulates myofibroblast differentiation and silica-induced pulmonary fibrosis.
Journal of translational medicine
Qu Y,Zhai R,Wang D,Wang Z,Hou G,Wu C,Tang M,Xiao X,Jiao J,Ba Y,Zhou F,Qiu J,Yao W
Tue Jun 06 00:00:00 UTC 2023
Mitochondrial folate pathway regulates myofibroblast differentiation and silica-induced pulmonary fibrosis.
Journal of translational medicine
Qu Y,Zhai R,Wang D,Wang Z,Hou G,Wu C,Tang M,Xiao X,Jiao J,Ba Y,Zhou F,Qiu J,Yao W
Tue Jun 06 00:00:00 UTC 2023
Mitochondrial folate pathway regulates myofibroblast differentiation and silica-induced pulmonary fibrosis.
Journal of translational medicine
Qu Y,Zhai R,Wang D,Wang Z,Hou G,Wu C,Tang M,Xiao X,Jiao J,Ba Y,Zhou F,Qiu J,Yao W
Tue Jun 06 00:00:00 UTC 2023
Mitochondrial folate pathway regulates myofibroblast differentiation and silica-induced pulmonary fibrosis.
Journal of translational medicine
Qu Y,Zhai R,Wang D,Wang Z,Hou G,Wu C,Tang M,Xiao X,Jiao J,Ba Y,Zhou F,Qiu J,Yao W
Tue Jun 06 00:00:00 UTC 2023
Mitochondrial folate pathway regulates myofibroblast differentiation and silica-induced pulmonary fibrosis.
Journal of translational medicine
Qu Y,Zhai R,Wang D,Wang Z,Hou G,Wu C,Tang M,Xiao X,Jiao J,Ba Y,Zhou F,Qiu J,Yao W
Tue Jun 06 00:00:00 UTC 2023
Mitochondrial folate pathway regulates myofibroblast differentiation and silica-induced pulmonary fibrosis.
Journal of translational medicine
Qu Y,Zhai R,Wang D,Wang Z,Hou G,Wu C,Tang M,Xiao X,Jiao J,Ba Y,Zhou F,Qiu J,Yao W
Tue Jun 06 00:00:00 UTC 2023
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.
EMBO molecular medicine
Southwell N,Primiano G,Nadkarni V,Attarwala N,Beattie E,Miller D,Alam S,Liparulo I,Shurubor YI,Valentino ML,Carelli V,Servidei S,Gross SS,Manfredi G,Chen Q,D'Aurelio M
Mon Jul 10 00:00:00 UTC 2023
An LKB1-mitochondria axis controls TH17 effector function.
Nature
Baixauli F,Piletic K,Puleston DJ,Villa M,Field CS,Flachsmann LJ,Quintana A,Rana N,Edwards-Hicks J,Matsushita M,Stanczak MA,Grzes KM,Kabat AM,Fabri M,Caputa G,Kelly B,Corrado M,Musa Y,Duda KJ,Mittler G,O'Sullivan D,Sesaki H,Jenuwein T,Buescher JM,Pearce EJ,Sanin DE,Pearce EL
Sat Oct 01 00:00:00 UTC 2022
Transcriptome and Proteome Analysis in LUHMES Cells Overexpressing Alpha-Synuclein.
Frontiers in neurology
Höllerhage M,Stepath M,Kohl M,Pfeiffer K,Chua OWH,Duan L,Hopfner F,Eisenacher M,Marcus K,Höglinger GU
Sat Apr 30 00:00:00 UTC 2022
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling.
Molecular cell
Fiore A,Zeitler L,Russier M,Groß A,Hiller MK,Parker JL,Stier L,Köcher T,Newstead S,Murray PJ
Thu Mar 03 00:00:00 UTC 2022
ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.
Molecular cell
Di Marcantonio D,Martinez E,Kanefsky JS,Huhn JM,Gabbasov R,Gupta A,Krais JJ,Peri S,Tan Y,Skorski T,Dorrance A,Garzon R,Goldman AR,Tang HY,Johnson N,Sykes SM
Thu Jul 01 00:00:00 UTC 2021
Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin.
Molecular metabolism
Byles V,Cormerais Y,Kalafut K,Barrera V,Hughes Hallett JE,Sui SH,Asara JM,Adams CM,Hoxhaj G,Ben-Sahra I,Manning BD
Mon Nov 01 00:00:00 UTC 2021
Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L-formate axis.
Journal of pineal research
Cui L,Zhao X,Jin Z,Wang H,Yang SF,Hu S
Wed Dec 01 00:00:00 UTC 2021
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals.
eLife
Torrence ME,MacArthur MR,Hosios AM,Valvezan AJ,Asara JM,Mitchell JR,Manning BD
Mon Mar 01 00:00:00 UTC 2021
Adaptation of the heart to Frataxin depletion: Evidence that integrated stress response can predominate over mTORC1 activation.
Human molecular genetics
Vásquez-Trincado C,Patel M,Sivaramakrishnan A,Bekeová C,Anderson-Pullinger L,Wang N,Tang HY,Seifert EL
Wed Sep 22 00:00:00 UTC 2021
The Prognostic Significance of Immune-Related Metabolic Enzyme MTHFD2 in Head and Neck Squamous Cell Carcinoma.
Diagnostics (Basel, Switzerland)
Cui L,Chen H,Zhao X
Fri Sep 11 00:00:00 UTC 2020
Cytosolic ME1 integrated with mitochondrial IDH2 supports tumor growth and metastasis.
Redox biology
Shao C,Lu W,Du Y,Yan W,Bao Q,Tian Y,Wang G,Ye H,Hao H
Tue Sep 01 00:00:00 UTC 2020
mTOR Overcomes Multiple Metabolic Restrictions to Enable HIV-1 Reverse Transcription and Intracellular Transport.
Cell reports
Taylor HE,Calantone N,Lichon D,Hudson H,Clerc I,Campbell EM,D'Aquila RT
Tue Jun 23 00:00:00 UTC 2020
Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death.
Nature communications
Balsa E,Perry EA,Bennett CF,Jedrychowski M,Gygi SP,Doench JG,Puigserver P
Mon Jun 01 00:00:00 UTC 2020
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
Human molecular genetics
Liu YT,Huang X,Nguyen D,Shammas MK,Wu BP,Dombi E,Springer DA,Poulton J,Sekine S,Narendra DP
Wed Jun 03 00:00:00 UTC 2020
Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder.
Proceedings of the National Academy of Sciences of the United States of America
Chen CW,Wang HL,Huang CW,Huang CY,Lim WK,Tu IC,Koorapati A,Hsieh ST,Kan HW,Tzeng SR,Liao JC,Chong WM,Naroditzky I,Kidron D,Eran A,Nijim Y,Sela E,Feldman HB,Kalfon L,Raveh-Barak H,Falik-Zaccai TC,Elpeleg O,Mandel H,Chang ZF
Tue Jan 08 00:00:00 UTC 2019
Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder.
Proceedings of the National Academy of Sciences of the United States of America
Chen CW,Wang HL,Huang CW,Huang CY,Lim WK,Tu IC,Koorapati A,Hsieh ST,Kan HW,Tzeng SR,Liao JC,Chong WM,Naroditzky I,Kidron D,Eran A,Nijim Y,Sela E,Feldman HB,Kalfon L,Raveh-Barak H,Falik-Zaccai TC,Elpeleg O,Mandel H,Chang ZF
Tue Jan 08 00:00:00 UTC 2019
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.
Cell metabolism
Wang LW,Shen H,Nobre L,Ersing I,Paulo JA,Trudeau S,Wang Z,Smith NA,Ma Y,Reinstadler B,Nomburg J,Sommermann T,Cahir-McFarland E,Gygi SP,Mootha VK,Weekes MP,Gewurz BE
Tue Sep 03 00:00:00 UTC 2019
The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines.
OncoTargets and therapy
Wei Y,Liu P,Li Q,Du J,Chen Y,Wang Y,Shi H,Wang Y,Zhang H,Xue W,Gao Y,Li D,Feng Y,Yan J,Han J,Zhang J
Sun Apr 10 00:00:00 UTC 2022
mTOR-S6K1 pathway mediates cytoophidium assembly.
Journal of genetics and genomics = Yi chuan xue bao
Sun Z,Liu JL
Fri Feb 01 00:00:00 UTC 2019
De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues.
The Journal of biological chemistry
Fan TWM,Bruntz RC,Yang Y,Song H,Chernyavskaya Y,Deng P,Zhang Y,Shah PP,Beverly LJ,Qi Z,Mahan AL,Higashi RM,Dang CV,Lane AN
Fri Sep 06 00:00:00 UTC 2019
Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.
Cell metabolism
Dogan SA,Cerutti R,Benincá C,Brea-Calvo G,Jacobs HT,Zeviani M,Szibor M,Viscomi C
Tue Nov 06 00:00:00 UTC 2018
Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.
Cell metabolism
Dogan SA,Cerutti R,Benincá C,Brea-Calvo G,Jacobs HT,Zeviani M,Szibor M,Viscomi C
Tue Nov 06 00:00:00 UTC 2018
Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase.
Cell reports
Lin WC,Chakraborty A,Huang SC,Wang PY,Hsieh YJ,Chien KY,Lee YH,Chang CC,Tang HY,Lin YT,Tung CS,Luo JD,Chen TW,Lin TY,Cheng ML,Chen YT,Yeh CT,Liu JL,Sung LY,Shiao MS,Yu JS,Chang YS,Pai LM
Tue Sep 04 00:00:00 UTC 2018
Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase.
Cell reports
Lin WC,Chakraborty A,Huang SC,Wang PY,Hsieh YJ,Chien KY,Lee YH,Chang CC,Tang HY,Lin YT,Tung CS,Luo JD,Chen TW,Lin TY,Cheng ML,Chen YT,Yeh CT,Liu JL,Sung LY,Shiao MS,Yu JS,Chang YS,Pai LM
Tue Sep 04 00:00:00 UTC 2018
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.
Nature communications
Hitzel J,Lee E,Zhang Y,Bibli SI,Li X,Zukunft S,Pflüger B,Hu J,Schürmann C,Vasconez AE,Oo JA,Kratzer A,Kumar S,Rezende F,Josipovic I,Thomas D,Giral H,Schreiber Y,Geisslinger G,Fork C,Yang X,Sigala F,Romanoski CE,Kroll J,Jo H,Landmesser U,Lusis AJ,Namgaladze D,Fleming I,Leisegang MS,Zhu J,Brandes RP
Tue Jun 12 00:00:00 UTC 2018
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.
Nature communications
Hitzel J,Lee E,Zhang Y,Bibli SI,Li X,Zukunft S,Pflüger B,Hu J,Schürmann C,Vasconez AE,Oo JA,Kratzer A,Kumar S,Rezende F,Josipovic I,Thomas D,Giral H,Schreiber Y,Geisslinger G,Fork C,Yang X,Sigala F,Romanoski CE,Kroll J,Jo H,Landmesser U,Lusis AJ,Namgaladze D,Fleming I,Leisegang MS,Zhu J,Brandes RP
Tue Jun 12 00:00:00 UTC 2018
Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation.
Cancer & metabolism
Koufaris C,Nilsson R
Mon Mar 21 00:00:00 UTC 2022
Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation.
Cancer & metabolism
Koufaris C,Nilsson R
Mon Mar 21 00:00:00 UTC 2022
Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation.
Cancer & metabolism
Koufaris C,Nilsson R
Mon Mar 21 00:00:00 UTC 2022
Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation.
Cancer & metabolism
Koufaris C,Nilsson R
Mon Mar 21 00:00:00 UTC 2022
mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression.
Cell metabolism
Khan NA,Nikkanen J,Yatsuga S,Jackson C,Wang L,Pradhan S,Kivelä R,Pessia A,Velagapudi V,Suomalainen A
Tue Aug 01 00:00:00 UTC 2017
mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression.
Cell metabolism
Khan NA,Nikkanen J,Yatsuga S,Jackson C,Wang L,Pradhan S,Kivelä R,Pessia A,Velagapudi V,Suomalainen A
Tue Aug 01 00:00:00 UTC 2017
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.
Science (New York, N.Y.)
Ben-Sahra I,Hoxhaj G,Ricoult SJH,Asara JM,Manning BD
Fri Feb 12 00:00:00 UTC 2016
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.
Science (New York, N.Y.)
Ben-Sahra I,Hoxhaj G,Ricoult SJH,Asara JM,Manning BD
Fri Feb 12 00:00:00 UTC 2016
Oxidative stress inhibits distant metastasis by human melanoma cells.
Nature
Piskounova E,Agathocleous M,Murphy MM,Hu Z,Huddlestun SE,Zhao Z,Leitch AM,Johnson TM,DeBerardinis RJ,Morrison SJ
Thu Nov 12 00:00:00 UTC 2015
Oxidative stress inhibits distant metastasis by human melanoma cells.
Nature
Piskounova E,Agathocleous M,Murphy MM,Hu Z,Huddlestun SE,Zhao Z,Leitch AM,Johnson TM,DeBerardinis RJ,Morrison SJ
Thu Nov 12 00:00:00 UTC 2015
Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus.
PloS one
Sugiyama K,Ebinuma H,Nakamoto N,Sakasegawa N,Murakami Y,Chu PS,Usui S,Ishibashi Y,Wakayama Y,Taniki N,Murata H,Saito Y,Fukasawa M,Saito K,Yamagishi Y,Wakita T,Takaku H,Hibi T,Saito H,Kanai T
Mon Jun 29 00:00:00 UTC 2015
Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus.
PloS one
Sugiyama K,Ebinuma H,Nakamoto N,Sakasegawa N,Murakami Y,Chu PS,Usui S,Ishibashi Y,Wakayama Y,Taniki N,Murata H,Saito Y,Fukasawa M,Saito K,Yamagishi Y,Wakita T,Takaku H,Hibi T,Saito H,Kanai T
Mon Jun 29 00:00:00 UTC 2015
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
Cancer cell
Mitsuishi Y,Taguchi K,Kawatani Y,Shibata T,Nukiwa T,Aburatani H,Yamamoto M,Motohashi H
Tue Jul 10 00:00:00 UTC 2012
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
Cancer cell
Mitsuishi Y,Taguchi K,Kawatani Y,Shibata T,Nukiwa T,Aburatani H,Yamamoto M,Motohashi H
Tue Jul 10 00:00:00 UTC 2012
