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Proteintech
MTHFD2 Polyclonal Antibody
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Product Details
12270-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MTHFD2 Fusion Protein Ag2911 (1-350 aa encoded by BC017054)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAATSLMSA LAARLLQPAH SCSLRLRPFH LAAVRNEAVV ISGRKLAQQI KQEVRQEVEE WVASGNKRPH LSVILVGENP ASHSYVLNKT RAAAVVGINS ETIMKPASIS EEELLNLINK LNNDDNVDGL LVQLPLPEHI DERRICNAVS PDKDVDGFHV INVGRMCLDQ YSMLPATPWG VWEIIKRTGI PTLGKNVVVA GRSKNVGMPI AMLLHTDGAH ERPGGDATVT ISHRYTPKEQ LKKHTILADI VISAAGIPNL ITADMIKEGA AVIDVGINRV HDPVTAKPKL VGDVDFEGVR QKAGYITPVP GGVGPMTVAM LMKNTIIAAK KVLRLEEREV LKSKELGVAT N (1-350 aa encoded by BC017054)
Target Information
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase; methylenetetrahydrofolate dehydrogenase 2; NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase
Gene Aliases: AW558851; MTHFD2; NMDMC
UniProt ID: (Human) P13995, (Mouse) P18155
Entrez Gene ID: (Human) 10797, (Mouse) 17768, (Rat) 680308
magnesium ion binding
formate-tetrahydrofolate ligase activity
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NAD+) activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
phosphate ion binding
catalytic activity
oxidoreductase activity
hydrolase activity
molecular_function
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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