Immunogen sequence: AAAAVSSAKRS LRGELKQRLR AMSAEERLRQ SRVLSQKVIA HSEYQKSKRI SIFLSMQDEI ETEEIIKDIF QRGKICFIPR YRFQSNHMDM VRIESPEEIS
Highest antigen sequence identity to the following orthologs - mouse 79%, rat 79%.
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 5,10-methenyl-tetrahydrofolate synthetase; 5-formyltetrahydrofolate cyclo-ligase; FLJ30410; methenyl-THF synthetase; MTHFS
Gene Aliases: HsT19268; MTHFS
UniProt ID: (Human) P49914
Entrez Gene ID: (Human) 10588
Molecular Function: ligase