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FIGURE: 1 / 4
MTM1 Antibody (H00004534-D01P) in WB
Western Blot analysis of MTM1 expression in transfected 293T cell line (H00004534-T01) by MTM1 MaxPab polyclonal antibody.
Lane 1: MTM1 transfected lysate(69.90 KDa).
Lane 2: Non-transfected lysate.
Lane 1: MTM1 transfected lysate(69.90 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00004534-D01P
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MTM1 (AAH30779.1, 1 a.a. approximately 603 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MASASTSKYN SHSLENESIK RTSRDGVNRD LTEAVPRLPG ETLITDKEVI YICPFNGPIK GRVYITNYRL YLRSLETDSS LILDVPLGVI SRIEKMGGAT SRGENSYGLD ITCKDMRNLR FALKQEGHSR RDMFEILTRY AFPLAHSLPL FAFLNEEKFN VDGWTVYNPV EEYRRQGLPN HHWRITFINK CYELCDTYPA LLVVPYRASD DDLRRVATFR SRNRIPVLSW IHPENKTVIV RCSQPLVGMS GKRNKDDEKY LDVIRETNKQ ISKLTIYDAR PSVNAVANKA TGGGYESDDA YHNAELFFLD IHNIHVMRES LKKVKDIVYP NVEESHWLSS LESTHWLEHI KLVLTGAIQV ADKVSSGKSS VLVHCSDGWD RTAQLTSLAM LMLDSFYRSI EGFEILVQKK WISFGHKFAS RIGHGDKNHT DADRSPIFLQ FIDCVWQMSK QFPTAFEFNE QFLIIILDHL YSCRFGTFLF NCESARERQK VTERTVSLWS LINSNKEKFK NPFYTKEINR VLYPVASMRH LELWVNYYIR WNPRIKQQQP NPVEQRYMEL LALRDEYIKR LEELQLANSA KLSDPPTSPS SPSQMMPHVQ THF
Target Information
Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regulating PI 3-K activity and by facilitating the degradation of PI 3-P.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Myotubularin; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase
Gene Aliases: AF073996; CG2; CNM; mKIAA4176; Mtm; MTM1; MTMX; XLMTM
UniProt ID: (Human) Q13496, (Mouse) Q9Z2C5
Entrez Gene ID: (Human) 4534, (Mouse) 17772
phosphatidylinositol-3-phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
protein binding
intermediate filament binding
phosphatidylinositol binding
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
hydrolase activity
phosphatase activity
phosphatase
protein dephosphorylation
phosphatidylinositol biosynthetic process
endosome to lysosome transport
protein transport
negative regulation of TOR signaling
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
peptidyl-tyrosine dephosphorylation
regulation of vacuole organization
intermediate filament organization
muscle cell cellular homeostasis
phosphatidylinositol dephosphorylation
mitochondrion distribution
positive regulation of skeletal muscle tissue growth
negative regulation of protein kinase B signaling
mitochondrion morphogenesis
negative regulation of autophagosome assembly
lipid metabolic process
transport
dephosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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