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This antibody is predicted to react with bovine, canine and mouse based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regulating PI 3-K activity and by facilitating the degradation of PI 3-P.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Myotubularin; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase
Gene Aliases: AF073996; CG2; CNM; mKIAA4176; Mtm; MTM1; MTMX; XLMTM
UniProt ID: (Human) Q13496, (Mouse) Q9Z2C5
Entrez Gene ID: (Human) 4534, (Mouse) 17772
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