Invitrogen

MTMR14 Polyclonal Antibody

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MTMR14 Antibody in Western Blot (WB) — Western Blot analysis of MTMR14 in extracts of various cell lines using MTMR14 Polyclonal Antibody (Product # PA5-96694) at a dilution of 1:1000. A HRP Goat Anti-Rabbit IgG (H+L) secondary antibody was used at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.

Product Details

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500 - 1:2000

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human MTMR14.

Conjugate

Unconjugated

Form

Liquid

Concentration

4.92 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2808496

Product Specific Information

Immunogen sequence: MAGARAAAAA ASAGSSASSG NQPPQELGLG ELLEEFSRTQ YRAKDGSGTG GSKVERIEKR CLELFGRDYC FSVIPNTNGD ICGHYPRHIV FLEYESSEKE KDTFESTVQV SKLQDLIHRS KMARCRGRFV CPVILFKGKH ICRSATLAGW GELYGRSGYN YFFSGGADDA WADVEDVTEE DCALRSGDTH LFDKVRGYDI KLLRYLSVKY ICDLMVENKK VKFGMNVTSS EKVDKAQRYA DFTLLSIPYP GCEFFKEYKD RDYMAEGLIF NWKQDYVDAP; Positive Samples: BT-474, Jurkat, Mouse liver, Mouse spleen, Mouse testis, Rat brain; Cellular Location: Cytoplasm

Target Information

This gene encodes a myotubularin-related protein. The encoded protein is a phosphoinositide phosphatase that specifically dephosphorylates phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 3-phosphate. Mutations in this gene are correlated with autosomal dominant centronuclear myopathy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 18.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: egg-derived tyrosine phosphatase homolog; HCV NS5A-transactivated protein 4 splice variant A-binding protein 1; hJumpy; jumpy; mJumpy; Myotubularin-related protein 14; NS5ATP4ABP1

Gene Aliases: 1110061O04Rik; AW553738; C3orf29; C76151; MTMR14; RGD1304842

UniProt ID: (Human) Q8NCE2, (Mouse) Q8VEL2

Entrez Gene ID: (Human) 64419, (Mouse) 97287, (Rat) 312634

Function(s)

dephosphorylation peptidyl-tyrosine dephosphorylation phosphatidylinositol biosynthetic process macroautophagy

Process(es)