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Positive test controls include: 293T, HepG2, Mouse brain, Mouse liver. The target is usually found in the following locations: Cytoplasm, Membrane, Peripheral membrane protein.
Immunogen sequence: GEATPRRLLS YGCCSKRPNS KQMRATGPCF GGQWAQREGV KSPVCSSHSN GHCTGPGGKN QMWLSSHPKQ VSSTKPVPLN CPSPVPPLYL DDDGLPFPTD VIQHRLRQIE AGYKQEVEQL RRQVRELQMR LDIRHCCAPP AEPPMDYEDD FTCLKESDGS DTEDFGSDHS EDCLSEASWE PVDKKETEVT RWVPDHMASH CYNCDCEFWL AKRRHHCRNC GNVFCAGCCH LKLPIPDQQL YDPVLVCNSC YEHIQVSRAR ELMSQQLKKP IATASS
MTMR, a member of the myotubularin family, encodes an intracellular protein of 1, 195 amino acids, and shares approximately 47% sequence identity with MTMR3, spiking to over 70% identity in the catalytic domain and the double zinc finger (FYVE) motif. PCR analysis detects expression of MTMR4 in all human tissues examined except lung, small intestine, stomach, salivary gland, adrenal gland, and uterus. Subcellular localization of MTMR4 in transfected HeLa cells showed a perinuclear distribution, similar to that seen with MTMR3. MTMR4 dephosphorylates para-nitrophenylphosphate and phosphatidylinositol 3-phosphate.
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Protein Aliases: DKFZp781E194; FYVE domain-containing dual specificity protein phosphatase 2; FYVE zinc finger phosphatase; FYVE-DSP2; MGC163449; MGC163451; MTMR7; Myotubularin-related protein 4; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4; Phosphatidylinositol-3-phosphate phosphatase; Zinc finger FYVE domain-containing protein 11; zinc finger, FYVE domain containing 11
Gene Aliases: AA596759; ESTM44; FYVE-DSP2; KIAA0647; mKIAA0647; MTMR4; ZFYVE11
UniProt ID: (Human) Q9NYA4, (Mouse) Q91XS1
Entrez Gene ID: (Human) 9110, (Mouse) 170749
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