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Proteintech
MTSS1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
13995-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MTSS1 fusion protein Ag5080
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.4 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SQDAFQSKSP SPMPPEAPNQ RRKEKREPDP NGGGPTTASG PPAAAEEAQR PRSMTVSAAT RPGEEMEACE ELALALSRGL QLDTQRSSRD SLQCSSGYST QTTTPCCSED TIPSQVSDYD YFSVSGDQEA DQQEFDKSST IPRNSDISQS YRRMFQAKRP ASTAGLPTTL GPAMVTPGVA TIRRTPSTKP SVRRGTIGAG PIPIKTPVIP VKTPTVPDLP GVLPAPPDGP EERGEHSPES PSVGEGPQGV TSMPSSMWSG QASVNPPLPG PKPSIPEEHR QAIPESEAED QEREPPSATV SPGQIPESDP ADLSPRDTPQ GEDMLNAIRR GVKLKKTTTN DRSAPRFS
Target Information
Metastasis suppressor protein 1 (MTSS1) [MIM, "missing in metastasis"], was first discovered as missing transcripts from metastatic bladder and prostate cancer cells. MTSS1 is a 755 amino acid protein, having multidomain and scaffolding function. It has a proline-rich/SH3 binding region and a serine-rich region with EGF or PDGF/Src consensus sites. It contains anactin-binding Wiskott-Aldrich syndrome protein homology-2 motif (WH2) at the C-terminus while the N-terminal IMD domain (IRSp53-MIM domain) interact with membranes and bundle actin filament. The WH2 domain binds to actin monomers and plays an important role in actin cytoskeleton reorganization. Recently, MIM was found to interact with cortactin via SH3 domains. In addition, MTSS1 enhanced cortactin- and Arp2/3-dependent actin polymerization. It is thus involved in cell motility and morphogenesis and also interacts with sonic hedgehog/Gli signaling in epidermal cells. MTSS1 acts as an important regulator of cell growth and development and is known to express in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: actin monomer-binding protein; interacts with ATP-G-actin through its C-terminal WH2 domain; KIAA0429; metastasis suppressor 1; metastasis suppressor protein 1; metastasis suppressor YGL-1; missing in metastasis protein; MTSS1, I-BAR domain containing; predicted protein of HQ1941; unnamed protein product
Gene Aliases: 2310003N14Rik; D130001D01Rik; MIM; MIMA; MIMB; mKIAA0429
UniProt ID: (Human) O43312, (Mouse) Q8R1S4
Entrez Gene ID: (Human) 9788, (Mouse) 211401, (Rat) 362918
plasma membrane organization
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
microspike assembly
actin cytoskeleton organization
positive regulation of actin filament bundle assembly
adherens junction maintenance
negative regulation of epithelial cell proliferation
renal tubule morphogenesis
cellular response to fluid shear stress
glomerulus morphogenesis
nephron tubule epithelial cell differentiation
epithelial cell proliferation involved in renal tubule morphogenesis
in utero embryonic development
actin filament organization
nervous system development
muscle organ development
magnesium ion homeostasis
actin filament polymerization
bone mineralization
metanephric tubule development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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