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Invitrogen
MX1 Polyclonal Antibody
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FIGURE: 1 / 22
MX1 Antibody (PA5-22101) in ICC/IF
Immunofluorescence analysis of MX1 was performed using 70% confluent log phase HeLa and HeLa cells treated with IFN Alpha (10 ng/mL, 16hrs). The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with MX1 Polyclonal Antibody (Product # PA5-22101) at 1:100 dilution in 0.1% BSA, incubated at 4 degree Celsius overnight and then with Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alex... View More
Product Details
PA5-22101
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Non-human primate,
Rabbit
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human MX1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.23 mg/mL
Amount
123 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: Jurkat, Raji, NCI-H929, human MX1-transfected 293T.
Predicted reactivity: Rhesus Monkey (92%), Chimpanzee (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GTP-binding protein; IFI-78K; Interferon-induced GTP-binding protein Mx1; Interferon-induced protein p78; interferon-inducible myxovirus resistance-1 protein; interferon-inducible protein p78; Interferon-regulated resistance GTP-binding protein MxA; Myxoma resistance protein 1; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78; Myxovirus resistance protein 1; p78 protein; unnamed protein product
Gene Aliases: IFI-78K; IFI78; lncMX1-215; MX; MX1; Mx1-b; Mx1B; MxA
UniProt ID: (Bovine) P79135, (Human) P20591
Entrez Gene ID: (Bovine) 280872, (Rabbit) 100359014, (Human) 4599
response to virus
response to type I interferon
response to type III interferon
negative regulation of viral genome replication
innate immune response
defense response to virus
immune system process
apoptotic process
defense response
signal transduction
synaptic vesicle budding from presynaptic endocytic zone membrane
interleukin-27-mediated signaling pathway
antiviral innate immune response
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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