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Product Details
PA5-68829
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of mouse MYBBP1A
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2688991
Product Specific Information
This target displays homology in the following species: Cow: 79%; Dog: 92%; Horse: 92%; Human: 86%; Mouse: 100%; Pig: 92%; Rat: 100%
Target Information
The Myb family of transcription factors, which includes the structurally related A-, B-, and c-Myb genes, regulate differentiation, cellular growth and transactivating gene expression. c-Myb plays an essential role in controlling the proliferation and differentiation of hematopoietic cells, cellular levels of c-Myb decreasing as cells reach terminal differentiation. Myb-binding protein 1A (MYBBP1A) is a novel nuclear protein localized predominantly, but not exclusively, in nucleoli. Although initially isolated as a c-Myb-interacting protein, MYBBP1A is expressed ubiquitously, and associates with a number of different transcription factors. MYBBP1A associates with the aromatic hydrocarbon receptor (AhR), enhancing transactivation and increasing AhR-dependent gene expression. MYBBP1A is a powerful negative regulator of PPAR gamma coactivator 1 alpha (PGC-1 alpha) by p38 MAPK and also acts as a nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and independent nuclear export pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Myb-binding protein 1A; Myb-binding protein of 160 kDa; nuclear protein P160
Gene Aliases: AL024407; AU019902; Mybbp1a; P160; p160MBP; p67MBP
UniProt ID: (Mouse) Q7TPV4
Entrez Gene ID: (Mouse) 18432
osteoblast differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
nucleocytoplasmic transport
respiratory electron transport chain
circadian regulation of gene expression
cellular response to glucose starvation
negative regulation of transcription, DNA-templated
rhythmic process
positive regulation of cell cycle arrest
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of anoikis
Performance Guarantee
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