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Product Details
PA5-96287
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1104-1328 of human MYBBP1A (NP_0553352)
Conjugate
Form
Liquid
Concentration
0.60 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2808089
Product Specific Information
Immunogen sequence: DLTVLLGVLQ GQQQSLQQGA HSTGSSRLHD LYWQAMKTLG VQRPKLEKKD AKEIPSATQS PISKKRKKKG FLPETKKRKK RKSEDGTPAE DGTPAATGGS QPPSMGRKKR NRTKAKVPAQ ANGTPTTKSP APGAPTRSPS TPAKSPKLQK KNQKPSQVNG APGSPTEPAG QKQHQKALPK KGVLGKSPLS ALARKKARLS LVIRSPSLLQ SGAKKKAQVR KAGKP; Positive Samples: HeLa, SW620, MCF7, Mouse liver, Rat liver; Cellular Location: Cytoplasm, Nucleus, nucleolus
Target Information
The Myb family of transcription factors, which includes the structurally related A-, B-, and c-Myb genes, regulate differentiation, cellular growth and transactivating gene expression. c-Myb plays an essential role in controlling the proliferation and differentiation of hematopoietic cells, cellular levels of c-Myb decreasing as cells reach terminal differentiation. Myb-binding protein 1A (MYBBP1A) is a novel nuclear protein localized predominantly, but not exclusively, in nucleoli. Although initially isolated as a c-Myb-interacting protein, MYBBP1A is expressed ubiquitously, and associates with a number of different transcription factors. MYBBP1A associates with the aromatic hydrocarbon receptor (AhR), enhancing transactivation and increasing AhR-dependent gene expression. MYBBP1A is a powerful negative regulator of PPAR gamma coactivator 1 alpha (PGC-1 alpha) by p38 MAPK and also acts as a nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and independent nuclear export pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MYB binding protein 1a; MYB binding protein (P160) 1a; Myb-binding protein 1A; Myb-binding protein of 160 kDa; nuclear protein P160; p53-activated protein-2; PAR interacting protein; PAR-interacting protein; PIP
Gene Aliases: AL024407; AU019902; DBP; MYBBP1A; P160; p160MBP; p67MBP; PAP2
UniProt ID: (Human) Q9BQG0, (Rat) O35821, (Mouse) Q7TPV4
Entrez Gene ID: (Human) 10514, (Rat) 60571, (Mouse) 18432
osteoblast differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
nucleocytoplasmic transport
respiratory electron transport chain
circadian regulation of gene expression
cellular response to glucose starvation
positive regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of cell cycle arrest
DNA biosynthetic process
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of anoikis
rhythmic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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