The Myb family of transcription factors, which includes the structurally related A-, B-, and c-Myb genes, regulate differentiation, cellular growth and transactivating gene expression. c-Myb plays an essential role in controlling the proliferation and differentiation of hematopoietic cells, cellular levels of c-Myb decreasing as cells reach terminal differentiation. Myb-binding protein 1A (MYBBP1A) is a novel nuclear protein localized predominantly, but not exclusively, in nucleoli. Although initially isolated as a c-Myb-interacting protein, MYBBP1A is expressed ubiquitously, and associates with a number of different transcription factors. MYBBP1A associates with the aromatic hydrocarbon receptor (AhR), enhancing transactivation and increasing AhR-dependent gene expression. MYBBP1A is a powerful negative regulator of PPAR gamma coactivator 1 alpha (PGC-1 alpha) by p38 MAPK and also acts as a nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and independent nuclear export pathways.
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Protein Aliases: MYB binding protein (P160) 1a; Myb-binding protein 1A; p53-activated protein-2
Gene Aliases: MYBBP1A; P160; PAP2
UniProt ID: (Human) Q9BQG0
Entrez Gene ID: (Human) 10514