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Invitrogen
MYBPC3 Polyclonal Antibody
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MYBPC3 Antibody (PA5-71701) in IHC (P)
Immunohistochemistry analysis of MYBPC3 in paraformaldehyde-fixed, paraffin-embedded human skeletal muscle tissue sections. Samples were incubated with MYBPC3 polyclonal antibody (Product # PA5-71701) using a dilution of 1:25 for 1 hours at 37°C followed by an undiluted biotinylated goat polyvalent antibody. Tissue was fixed with formaldehyde and blocked with 3% BSA for 0.5 hour at room temperature; antigen... View More
Product Details
PA5-71701
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 189-218 amino acids from the N-terminal region of human MYBPC3
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Myosin binding protein C, cardiac-type (MYBPC3) is a thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments. It modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Mutations affecting the gene can result in cardiomyopathy - familial hypertrophic 4, cardiomyopathy - dilated 1MM, or left ventricular non-compaction 10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-protein, cardiac muscle isoform; cardiac C-protein; Cardiac MyBP-C; DKFZp779E1762; Myosin-binding protein C, cardiac-type; truncated cardiac myosin-binding protein C
Gene Aliases: CMD1MM; CMH4; FHC; LVNC10; MYBP-C; MYBPC3
UniProt ID: (Human) Q14896, (Rat) P56741
Entrez Gene ID: (Human) 4607, (Rat) 295929, (Mouse) 17868
regulation of heart rate
heart morphogenesis
muscle contraction
regulation of striated muscle contraction
cell adhesion
regulation of heart contraction
myosin filament assembly
sarcomere organization
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
muscle filament sliding
positive regulation of ATPase activity
regulation of muscle filament sliding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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