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MYH6 Polyclonal Antibody

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Antibody Testing Data (8)

MYH6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 8

MYH6 Antibody (22281-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human heart tissue slide using 22281-1-AP ( MYH6 Antibody) at dilution of 1:50 (under 40x lens).

MYH6 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

MYH6 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

22281-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:20,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 8 publications 8 publications

Immunoprecipitation (IP)

1:300

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Not applicable (N/A)

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.43 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located approximately 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Novel antioxidant peptides from MFGM protein Hydrolysates: Separation, identification and effects on Dexamethasone-induced mitochondrial dysfunction.

Food chemistry

Li H,Guan K,Liu M,Liu D,Wang W,Zhu A

Wed Mar 01 00:00:00 EST 2023

Neddylation is required for perinatal cardiac development through stimulation of metabolic maturation.

Cell reports

Zou J,Wang W,Lu Y,Ayala J,Dong K,Zhou H,Wang J,Chen W,Weintraub NL,Zhou J,Li J,Su H

Tue Jan 31 00:00:00 EST 2023

GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhang M,Tan Y,Song Y,Zhu M,Zhang B,Chen C,Liu Y,Shi L,Cui J,Shan W,Jia Z,Feng L,Cao G,Yi W,Sun Y

Mon May 01 00:00:00 EDT 2023

Independent regulation of Z-lines and M-lines during sarcomere assembly in cardiac myocytes revealed by the automatic image analysis software sarcApp.

bioRxiv : the preprint server for biology

Neininger-Castro AC,Hayes JB,Sanchez ZC,Taneja N,Fenix AM,Moparthi S,Vassilopoulos S,Burnette DT

Fri Oct 06 00:00:00 EDT 2023

Expression patterns and correlation analyses of muscle-specific genes in the process of sheep myoblast differentiation.

In vitro cellular & developmental biology. Animal

Wang H,Dou M,Li J,Cao P,Li J,Guo T,Zhao D,Khan A,Li Y,Li B,Qin J,Du R

Sat Oct 01 00:00:00 EDT 2022

Dihydromyricetin alters myosin heavy chain expression via AMPK signaling pathway in porcine myotubes.

Food & function

Guo Z,Chen X,Chen D,Yu B,He J,Zheng P,Luo Y,Chen H,Yan H,Huang Z

Mon Oct 17 00:00:00 EDT 2022

Appropriate Exogenous Expression Stoichiometry of GATA4 as an Important Factor for Cardiac Reprogramming of Human Dermal Fibroblasts.

Cellular reprogramming

Zhang X,Zhang Q,Chen L,Cai B,Zeng M,Ou S,Chen Y,Feng Z,Chen H,Cao S,Kang K

Sat Oct 01 00:00:00 EDT 2022

Engineering of thick human functional myocardium via static stretching and electrical stimulation.

iScience

Pretorius D,Kahn-Krell AM,LaBarge WC,Lou X,Zhang J

Fri Mar 18 00:00:00 EDT 2022

MYOCD is Required for Cardiomyocyte-like Cells Induction from Human Urine Cells and Fibroblasts Through Remodeling Chromatin.

Stem cell reviews and reports

Zhang X,Chen L,Huang X,Chen H,Cai B,Qin Y,Chen Y,Ou S,Li X,Wu Z,Feng Z,Zeng M,Guo W,Li H,Zhou C,Yu S,Pan M,Liu J,Kang K,Cao S,Pei D

Sat Oct 01 00:00:00 EDT 2022

Cellular Phenotypic Transformation in Heart Failure Caused by Coronary Heart Disease and Dilated Cardiomyopathy: Delineating at Single-Cell Level.

Biomedicines

Zhu L,Wang W,Ren C,Wang Y,Zhang G,Liu J,Wang W

Tue Feb 08 00:00:00 EST 2022

Cellular Phenotypic Transformation in Heart Failure Caused by Coronary Heart Disease and Dilated Cardiomyopathy: Delineating at Single-Cell Level.

Biomedicines

Zhu L,Wang W,Ren C,Wang Y,Zhang G,Liu J,Wang W

Tue Feb 08 00:00:00 EST 2022

Essential Role of Sptan1 in Cochlear Hair Cell Morphology and Function Via Focal Adhesion Signaling.

Molecular neurobiology

Yao Q,Wang H,Chen H,Li Z,Jiang Y,Li Z,Wang J,Xing Y,Liu F,Yu D,Yin S

Sat Jan 01 00:00:00 EST 2022

Fat mass and obesity-associated gene (FTO) hypermethylation induced by decabromodiphenyl ethane causing cardiac dysfunction via glucolipid metabolism disorder.

Ecotoxicology and environmental safety

Gao L,Zhang Y,Liu J,Li X,Sang Y,Zhou G,Xue J,Jing L,Shi Z,Wei J,Lu X,Zhou X

Wed Jun 01 00:00:00 EDT 2022

MicroRNA-124-3p affects myogenic differentiation of adipose-derived stem cells by targeting Caveolin-1 during pelvic floor dysfunction in Sprague Dawley rats.

Annals of translational medicine

Chen H,Li Z,Lin M,Lv X,Wang J,Wei Q,Zhang Z,Li L

Fri Jan 01 00:00:00 EST 2021

Amelioration of circadian disruption and calcium-handling protein defects by choline alleviates cardiac remodeling in abdominal aorta coarctation rats.

Laboratory investigation; a journal of technical methods and pathology

He X,Yang S,Deng J,Wu Q,Zang WJ

Thu Jul 01 00:00:00 EDT 2021

Sirtuin 3 deficiency aggravates angiotensin II-induced hypertensive cardiac injury by the impairment of lymphangiogenesis.

Journal of cellular and molecular medicine

Zhang C,Li N,Suo M,Zhang C,Liu J,Liu L,Qi Y,Zheng X,Xie L,Hu Y,Bu P

Sun Aug 01 00:00:00 EDT 2021

Differential roles of YTHDF1 and YTHDF3 in embryonic stem cell-derived cardiomyocyte differentiation.

RNA biology

Wang S,Zhang J,Wu X,Lin X,Liu XM,Zhou J

Wed Sep 01 00:00:00 EDT 2021

Asporin is a Potential Promising Biomarker for Common Heart Failure.

DNA and cell biology

Zhang K,Wu M,Qin X,Wen P,Wu Y,Zhuang J

Mon Feb 01 00:00:00 EST 2021

Age-dependent changes in electrophysiology and calcium handling: implications for pediatric cardiac research.

American journal of physiology. Heart and circulatory physiology

Swift LM,Burke M,Guerrelli D,Reilly M,Ramadan M,McCullough D,Prudencio T,Mulvany C,Chaluvadi A,Jaimes R,Posnack NG

Sat Feb 01 00:00:00 EST 2020

Senolytic Agent Navitoclax Inhibits Angiotensin II-Induced Heart Failure in Mice.

Journal of cardiovascular pharmacology

Jia K,Dai Y,Liu A,Li X,Wu L,Lu L,Bao Y,Jin Q

Thu Oct 01 00:00:00 EDT 2020

Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys⁴⁴ to prevent cardiac structural damage in diabetic cardiomyopathy.

British journal of pharmacology

Sun X,Zhao D,Lu F,Peng S,Yu M,Liu N,Sun Y,Du H,Wang B,Chen J,Dong S,Lu F,Zhang W

Sat Feb 01 00:00:00 EST 2020

Examination of the Effect of a 50-Hz Electromagnetic Field at 500 μT on Parameters Related With the Cardiovascular System in Rats.

Frontiers in public health

Zhang Y,Li L,Liu X,Ding L,Wu X,Wang J,He M,Hou H,Ruan G,Lai J,Chen C

Fri May 14 00:00:00 EDT 2021

Doxorubicin-induced cardiotoxicity involves IFNγ-mediated metabolic reprogramming in cardiomyocytes.

The Journal of pathology

Ni C,Ma P,Wang R,Lou X,Liu X,Qin Y,Xue R,Blasig I,Erben U,Qin Z

Fri Mar 01 00:00:00 EST 2019

Doxorubicin-induced cardiotoxicity involves IFNγ-mediated metabolic reprogramming in cardiomyocytes.

The Journal of pathology

Ni C,Ma P,Wang R,Lou X,Liu X,Qin Y,Xue R,Blasig I,Erben U,Qin Z

Fri Mar 01 00:00:00 EST 2019

Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions.

Developmental cell

Chopra A,Kutys ML,Zhang K,Polacheck WJ,Sheng CC,Luu RJ,Eyckmans J,Hinson JT,Seidman JG,Seidman CE,Chen CS

Mon Jan 08 00:00:00 EST 2018

Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions.

Developmental cell

Chopra A,Kutys ML,Zhang K,Polacheck WJ,Sheng CC,Luu RJ,Eyckmans J,Hinson JT,Seidman JG,Seidman CE,Chen CS

Mon Jan 08 00:00:00 EST 2018

Skeletal muscle in aged mice reveals extensive transformation of muscle gene expression.

BMC genetics

Lin IH,Chang JL,Hua K,Huang WC,Hsu MT,Chen YF

Wed Aug 08 00:00:00 EDT 2018

Region of Interest analysis using mass spectrometry imaging of mitochondrial and sarcomeric proteins in acute cardiac infarction tissue.

Scientific reports

Yajima Y,Hiratsuka T,Kakimoto Y,Ogawa S,Shima K,Yamazaki Y,Yoshikawa K,Tamaki K,Tsuruyama T

Thu May 10 00:00:00 EDT 2018

Region of Interest analysis using mass spectrometry imaging of mitochondrial and sarcomeric proteins in acute cardiac infarction tissue.

Scientific reports

Yajima Y,Hiratsuka T,Kakimoto Y,Ogawa S,Shima K,Yamazaki Y,Yoshikawa K,Tamaki K,Tsuruyama T

Thu May 10 00:00:00 EDT 2018

Overexpression of Cardiac-Specific Kinase TNNI3K Promotes Mouse Embryonic Stem Cells Differentiation into Cardiomyocytes.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Wang Y,Wang SQ,Wang LP,Yao YH,Ma CY,Ding JF,Ye J,Meng XM,Li JJ,Xu RX

Tue Jun 06 00:00:00 EDT 2017

Overexpression of Cardiac-Specific Kinase TNNI3K Promotes Mouse Embryonic Stem Cells Differentiation into Cardiomyocytes.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Wang Y,Wang SQ,Wang LP,Yao YH,Ma CY,Ding JF,Ye J,Meng XM,Li JJ,Xu RX

Tue Jun 06 00:00:00 EDT 2017

Overexpression of Cardiac-Specific Kinase TNNI3K Promotes Mouse Embryonic Stem Cells Differentiation into Cardiomyocytes.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Wang Y,Wang SQ,Wang LP,Yao YH,Ma CY,Ding JF,Ye J,Meng XM,Li JJ,Xu RX

Tue Jun 06 00:00:00 EDT 2017

Overexpression of Cardiac-Specific Kinase TNNI3K Promotes Mouse Embryonic Stem Cells Differentiation into Cardiomyocytes.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Wang Y,Wang SQ,Wang LP,Yao YH,Ma CY,Ding JF,Ye J,Meng XM,Li JJ,Xu RX

Tue Jun 06 00:00:00 EDT 2017

Distinctive Roles of Canonical and Noncanonical Wnt Signaling in Human Embryonic Cardiomyocyte Development.

Stem cell reports

Mazzotta S,Neves C,Bonner RJ,Bernardo AS,Docherty K,Hoppler S

Tue Oct 11 00:00:00 EDT 2016

Distinctive Roles of Canonical and Noncanonical Wnt Signaling in Human Embryonic Cardiomyocyte Development.

Stem cell reports

Mazzotta S,Neves C,Bonner RJ,Bernardo AS,Docherty K,Hoppler S

Tue Oct 11 00:00:00 EDT 2016

HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.

Science (New York, N.Y.)

Hinson JT,Chopra A,Nafissi N,Polacheck WJ,Benson CC,Swist S,Gorham J,Yang L,Schafer S,Sheng CC,Haghighi A,Homsy J,Hubner N,Church G,Cook SA,Linke WA,Chen CS,Seidman JG,Seidman CE

Fri Aug 28 00:00:00 EDT 2015

HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.

Science (New York, N.Y.)

Hinson JT,Chopra A,Nafissi N,Polacheck WJ,Benson CC,Swist S,Gorham J,Yang L,Schafer S,Sheng CC,Haghighi A,Homsy J,Hubner N,Church G,Cook SA,Linke WA,Chen CS,Seidman JG,Seidman CE

Fri Aug 28 00:00:00 EDT 2015

Bioinformatics

Protein Aliases: alpha cardiac MHC; alpha myosin; cardiac myosin heavy chain alpha isoform; cardiomyopathy, hypertrophic 1; MyHC-alpha; myosin 6; Myosin heavy chain 6; myosin heavy chain polypeptide 6 cardiac muscle adult; Myosin heavy chain, cardiac muscle alpha isoform; Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha); myosin heavy chain, cardiac muscle, adult; myosin heavy chain, polypeptide 6, cardiac muscle, alpha; myosin, heavy polypeptide 6, cardiac muscle, alpha; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1); Myosin-6

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Gene Aliases: A830009F23Rik; AA517445; alpha-MHC; ASD3; CMD1EE; CMH14; MYH6; MYHC; Myhc-a; MYHCA; SSS3

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UniProt ID: (Human) P13533, (Mouse) Q02566

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Entrez Gene ID: (Human) 4624, (Mouse) 17888, (Rat) 29556

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Function(s)

microfilament motor activity actin binding calmodulin binding ATP binding ATPase activity myosin phosphatase activity protein kinase binding actin-dependent ATPase activity nucleotide binding motor activity protein binding calcium-dependent ATPase activity identical protein binding protein homodimerization activity protein heterodimerization activity

Process(es)

in utero embryonic development regulation of the force of heart contraction regulation of heart rate muscle contraction striated muscle contraction adult heart development visceral muscle development regulation of heart contraction metabolic process regulation of blood pressure actin filament-based movement muscle filament sliding myofibril assembly BMP signaling pathway regulation of ATPase activity sarcomere organization ATP metabolic process cardiac muscle fiber development atrial cardiac muscle tissue morphogenesis ventricular cardiac muscle tissue morphogenesis cardiac muscle contraction canonical Wnt signaling pathway regulation of heart growth response to heat protein dephosphorylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MYH6 Polyclonal Antibody

MYH6 Antibody (22281-1-AP) in IHC (P)

Product Details

22281-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

Bioinformatics

Performance Guarantee

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