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Invitrogen
MYL9/MYL12 Polyclonal Antibody
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FIGURE: 1 / 2
MYL9/MYL12 Antibody (PA5-143725) in ICC/IF
Immunocytochemistry analysis of MYL9/MYL12 in paraformaldehyde fixed A7r5 cells. The cells were dual-labeled with anti-MLC antibody (middle) and MYL9/MYL12 polyclonal antibody (Product # PA5-143725) (top left), Phospho-MYL12A (Ser19) polyclonal antibody (Product # PA5-143727) (middle left) and Phospho-MYL12A (Ser1) polyclonal antibody (Product # PA5-143726) (bottom left). Goat anti-Mouse DyLight® 488 and Go... View More
Product Details
PA5-143725
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MLC synthetic peptide (coupled to KLH) corresponds to amino acid residues in the N-terminus of human myosin regulatory light chain 12A (Myl12A). This peptide sequence is highly conserved in human, rat, mouse, chicken, and zebrafish Myl12A, and in other smooth muscle and non-muscle MLCs.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1mg/mL BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects a 20 kDa* band corresponding to the molecular weight of myosin light chain in mouse C2C12, rat PC12, and human A431.
Target Information
Myosin regulatory light polypeptide 9 is a highly conserved, ubiquitously expressed protein that in humans is encoded by the MYL9 gene. Myosin, a structural component of muscle, are hexameric proteins consisting of two heavy chains and four light chains, including a single pair of nonphosphorylatable light chain subunits and another pair of phosphorylatable light chain subunits.The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. Myosin light chain (Myl) 9 and Myl12 are new functional ligands for CD69. Blockade of CD69-Myl9/12 interactio ameliorates allergic airway inflammation in ovalbumin-induced and house dust mite-induced mouse models of asthma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 20 kDa myosin light chain; brain specific myosin regulatory light chain; Epididymis secretory protein Li 24; epididymis secretory sperm binding protein; HEL-S-24; LC20; MLC-2; MLC-2A; MLC-2B; MLC-2C; MLC20; MYL9; myosin light chain, regulatory B; myosin light chain, regulatory B-like; myosin light chain, regulatory C; myosin regulatory light chain 1; Myosin regulatory light chain 12A; Myosin regulatory light chain 12B; myosin regulatory light chain 2; Myosin regulatory light chain 2, nonsarcomeric; Myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 2-A, smooth muscle isoform; Myosin regulatory light chain 2-B, smooth muscle isoform; Myosin regulatory light chain 20 kDa; myosin regulatory light chain 3; Myosin regulatory light chain 9; Myosin regulatory light chain MRLC1; Myosin regulatory light chain MRLC2; Myosin regulatory light chain MRLC3; Myosin regulatory light chain RLC-A; myosin regulatory light chain-B; Myosin regulatory light polypeptide 9; Myosin RLC; Myosin RLC-A; Myosin RLC-B; myosin, light chain 12A, regulatory, non-sarcomeric; myosin, light chain 12B, regulatory; myosin, light chain 9, regulatory; myosin, light polypeptide 9, regulatory; myosin, light polypeptide, regulatory, non-sarcomeric (20kD); NMDA receptor-interacting protein; SHUJUN-1; unnamed protein product
Gene Aliases: 1500001M02Rik; 2900073G15Rik; AI327049; AI838292; C77744; C80200; HEL-S-24; LC20; MLC-2B; MLC-2C; MLC-B; MLC2; MLC20; MLCB; MMIHS4; MRCL3; MRLC1; MRLC2; MRLC3; Mrlcb; MYL12A; MYL12B; MYL2B; MYL9; MYLC2B; Mylc2c; MYRL2; RGD1309537; RLC; Rlc-a; RLC-B; RLC-C
UniProt ID: (Human) P19105, (Human) O14950, (Human) P24844, (Rat) P13832, (Rat) P18666, (Mouse) Q3THE2, (Rat) Q64122, (Mouse) Q9CQ19
Entrez Gene ID: (Human) 10627, (Human) 103910, (Human) 10398, (Rat) 501203, (Mouse) 67268, (Rat) 50685, (Mouse) 67938, (Rat) 296313, (Mouse) 98932
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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