MYLPF (myosin light chain, phosphorylatable, fast skeletal muscle), also known as fast skeletal myosin light chain 2 or MLC2B, is a 169 amino acid protein that is expressed in fetal and adult skeletal muscle. A calcium binding protein, MYLPF contains three EF hand domains and is encoded by a gene that maps to human chromosome 16p11.2. Chromosome 16 encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth.
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Protein Aliases: DKFZp779C0757; DTNB; Fast skeletal myosin light chain 2; G2; MGC13450; MLC-2; MLC2B; MLC2F; myosin light chain; myosin light chain 2; Myosin light polypeptide 2 alkali; Myosin regulatory light chain 2, skeletal muscle isoform; myosin, light chain 11, regulatory; Myosin, light polypeptide 2, alkali; Myosin, light polypeptide 2, alkali; ventricular, skeletal, slow; ventricular skeletal slow; ventricular, skeletal, slow
Gene Aliases: 2410014J02Rik; HUMMLC2B; MLC-2; MLC2; MLC2B; MRLC2; MYL11; Myl2; MYLPF; Myolc1