Peptide sequence: LEELLTTQCD RFSQEEIKNM WAAFPPDVGG NVDYKNICYV ITHGDAKDQE
Sequence homology: Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 77%
MYLPF (myosin light chain, phosphorylatable, fast skeletal muscle), also known as fast skeletal myosin light chain 2 or MLC2B, is a 169 amino acid protein that is expressed in fetal and adult skeletal muscle. A calcium binding protein, MYLPF contains three EF hand domains and is encoded by a gene that maps to human chromosome 16p11.2. Chromosome 16 encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth.
Protein Aliases: DKFZp779C0757; DTNB; Fast skeletal myosin light chain 2; G2; MGC13450; MLC-2; MLC2B; MLC2F; myosin light chain; myosin light chain 2; myosin light chain, phosphorylatable, fast skeletal muscle; Myosin light polypeptide 2 alkali; Myosin regulatory light chain 2, skeletal muscle isoform; Myosin regulatory light chain 2, skeletal muscle isoform type 1; Myosin regulatory light chain 2, skeletal muscle isoform type 2; myosin regulatory light chain 2, skeletal muscle isoform type 2-like; myosin, light chain 11, regulatory; Myosin, light polypeptide 2, alkali; Myosin, light polypeptide 2, alkali; ventricular, skeletal, slow; phosphorylatable fast skeletal muscle myosin light chain; ventricular skeletal slow; ventricular, skeletal, slow
Gene Aliases: 2410014J02Rik; BOS_22882; HUMMLC2B; MLC-2; MLC2; MLC2B; MRLC2; MYL11; Myl2; MYLPF; Myolc1