PA5-32232 targets Myosin 1C in WB and IHC(P) applications and shows reactivity with Human samples.
The PA5-32232 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 1028 of Human Myosin 1C.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19.
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Protein Aliases: MMI-beta; MMIb; Myosin I beta; myosin-I beta; myosin-Ic; myr2; NMI; nuclear myosin I; Unconventional myosin-Ic
Gene Aliases: MMI-beta; MMIb; MYO1C; myr2; NMI
UniProt ID: (Human) O00159
Entrez Gene ID: (Human) 4641