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Proteintech
Myelin basic protein Polyclonal Antibody
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FIGURE: 1 / 10
Myelin basic protein Antibody (10458-1-AP) in IHC (P)
Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using (Product # 10458-1-AP) (Myelin basic protein antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
Product Details
10458-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Myelin basic protein Fusion Protein Ag0713 (1-171 aa encoded by BC008749)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
75 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
10458-1-AP is capable of recognizing multiple isoforms of MBP.
Immunogen sequence: MASQKRPSQ RHGSKYLATA STMDHARHGF LPRHRDTGIL DSIGRFFGGD RGAPKRGSGK DSHHPARTAH YGSLPQKSHG RTQDENPVVH FFKNIVTPRT PPPSQGKGRG LSLSRFSWGA EGQRPGFGYG GRASDYKSAH KGFKGVDAQG TLSKIFKLGG RDSRSGSPMA RR (1-171 aa encoded by BC008749)
Target Information
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 17.3K myelin basic protein; golli mbp; Golli-Mbp; myelin basic protein; Golli-Mbp; myelin basic protein; myelin basic protein S; MBP; MBP S; MGC99675; Myelin A1 protein; Myelin basic protein; myelin basic protein Golli-mbp; myelin basic protein S; myelin deficient; Myelin membrane encephalitogenic protein; shiverer; unnamed protein product
Gene Aliases: C76307; golli-mbp; Hmbpr; MBP; Mbps; mld; R75289; Shi
UniProt ID: (Human) P02686, (Rat) Q505J1, (Mouse) P04370
Entrez Gene ID: (Human) 4155, (Rat) 24547, (Mouse) 17196
MAPK cascade
immune response
chemical synaptic transmission
central nervous system development
sensory perception of sound
axon ensheathment
response to toxic substance
substantia nigra development
positive regulation of interleukin-6 production
negative regulation of heterotypic cell-cell adhesion
maintenance of blood-brain barrier
myelination
membrane organization
positive regulation of metalloendopeptidase activity
positive regulation of chemokine (C-X-C motif) ligand 2 production
aging
response to progesterone
response to tumor necrosis factor
response to mercury ion
negative regulation of axonogenesis
response to fatty acid
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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