Despite its predicted molecular weight, NADE often migrates at ~23kDa in SDS-PAGE. A suggested positive control is human brain tissue lysate.
PA5-20076 can be used with blocking peptide PEP-0194.
May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.
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Protein Aliases: brain expressed X-linked 3; brain expressed, X-linked 3; Brain-expressed X-linked protein 3; Brain-expressed X-linked protein 3 homolog; granule cell antiserum positive 27; nerve growth factor receptor (TNFRSF16) associated protein 1; Nerve growth factor receptor-associated protein 1; Ovarian granulosa cell 13.0 kDa protein HGR74; ovarian granulosa cell protein (13kD); p75NTR-associated Cell Death Executor; Protein BEX3; RP13-349O20.1, BEX3, Bex, DXS6984E, HGR74, NADE
Gene Aliases: AL033356; Bex; BEX3; DXS6984E; DXWsu67e; Gcap27; HGR74; NADE; NGFRAP1