Immunogen sequence: SEVLLVSEDG KILAEADGLS TNHWLIGTDK CVERINEMVN RAKRKAGVDP LVPLRSLGLS LSGGDQEDAG RILIEELRDR FPYLSE
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 88%.
SPG20 is a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GlcNAc kinase; N-acetyl-D-glucosamine kinase; N-acetylglucosamine kinase
Gene Aliases: GNK; HSA242910; NAGK
UniProt ID: (Human) Q9UJ70
Entrez Gene ID: (Human) 55577