Immunogen sequence: PDGSESGCGG WGHMMGDEGS AYWIAHQAVK IVFDSIDNLE AAPHDIGYVK QAMFHYFQVP DRLGILTHLY RDFDKCRFAG FCRKIAEGAQ QG
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
SPG20 is a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor.
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Protein Aliases: GlcNAc kinase; N-acetyl-D-glucosamine kinase; N-acetylglucosamine kinase
Gene Aliases: GNK; HSA242910; NAGK
UniProt ID: (Human) Q9UJ70
Entrez Gene ID: (Human) 55577