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Product Details
PA5-116672
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1370-1473 of human NLRP1 (NP_1274971)
Conjugate
Form
Liquid
Concentration
1.39 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2901303
Product Specific Information
Positive Samples: HeLa, SH-SY5Y
Immunogen sequence: PSPLDAPQLL HFVDQYREQL IARVTSVEVV LDKLHGQVLS QEQYERVLAE NTRPSQMRKL FSLSQSWDRK CKDGLYQALK ETHPHLIMEL WEKGSKKGLL PLSS
Target Information
NALP1 is a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: caspase recruitment domain protein; caspase recruitment domain protein 7; Caspase recruitment domain-containing protein 7; Death effector filament-forming ced-4-like apoptosis protein; DKFZp586O1822; nacht; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; NACHT, LRR and PYD domains-containing protein 1; NACHT, LRR and PYD domains-containing protein 1a; NACHT, LRR and PYD domains-containing protein 1a allele 1; NACHT/LRR/pyrin domain-containing protein 1; NLR family protein 1; NLR family, pyrin domain containing 1; NLR family, pyrin domain containing 1A; Nucleotide-binding domain and caspase recruitment domain; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1; resistant anthrax lethal toxin
Gene Aliases: CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; Gm14; Gm15; KIAA0926; NAC; NALP1; Nalp1a; NLRP1; Nlrp1a; PP1044; SLEV1; VAMAS1
UniProt ID: (Human) Q9C000, (Mouse) Q2LKU9, (Rat) D9I2F9
Entrez Gene ID: (Human) 22861, (Mouse) 195046, (Rat) 360557
response to muramyl dipeptide
defense response to bacterium
positive regulation of interleukin-1 beta secretion
programmed necrotic cell death
activation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of apoptotic process
neuron apoptotic process
apoptotic process
inflammatory response
innate immune response
regulation of inflammatory response
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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