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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 506 and 736 of Human NALP2|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:5000-1:20,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-29196 targets NALP2 in IF and WB applications and shows reactivity with Human samples.
The PA5-29196 immunogen is recombinant fragment corresponding to a region within amino acids 506 and 736 of Human NALP2.
NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CLR19.9; leucine rich repeat and PYD containing 2; LRR and PYD containing protein 2; LRR and PYD domains-containing protein 2; NACHT; NACHT, leucine rich repeat and PYD containing 2; NACHT, LRR and PYD containing protein 2; NALP2; NBS1; NLR family, pyrin domain containing 2; nucleotide-binding oligomeriza; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2; nucleotide-binding site protein 1; PAN1; PYPAF2; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2
CLR19.9; NALP2; NBS1; NLRP2; PAN1; PYPAF2