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Immunogen sequence: LLPESFLIVT VRDVGTEKLK SEVVSPRYLL VRGISGEQRI HLLLERGIGE HQKTQGLRAI MNNRELLDQC QVPAVGSLIC VALQLQDVVG ESVAPFNQTL TGLHAAFVFH QLTPR
Antigen sequence identity: Mouse 52%; Rat 50%
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Mater protein homolog; Maternal Antigen that Embryos Require; NACHT, leucine rich repeat and PYD containing 5; NACHT, LRR and PYD domains-containing protein 5; NLR family, pyrin domain containing 5; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 5
Gene Aliases: CLR19.8; MATER; NALP5; NLRP5; PAN11; PYPAF8
UniProt ID: (Human) P59047
Entrez Gene ID: (Human) 126206
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