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The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.
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Protein Aliases: B-box protein; Cell migration-inducing gene 19 protein; Membrane component chromosome 17 surface marker 2; Membrane component chromosome 17 surface marker 2 homolog; membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125); migration-inducing protein 19; neighbor of BRCA1 gene 1; Neighbor of BRCA1 gene 1 protein; Next to BRCA1 gene 1 protein; next to the Brca1; ovarian carcinoma antigen CA125; Protein 1A1-3B
Gene Aliases: 1A1-3B; 1A13B; Ca125; IAI3B; KIAA0049; M17S2; MIG19; mKIAA0049; NBR1; RGD1311421