|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG|
|Immunogen||A synthetic peptide from the human SMRT protein corresponding to amino acids 80-92 (QELHLRPESHSYL).|
|Storage buffer||PBS, pH 7.4|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunoprecipitation (IP)||Assay dependent|
|Western Blot (WB)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-23286 detects SMRT in Human samples.
PA1-23286 has been successfully used in Immunoprecipitation and Western Blot procedures.
PA1-23286 immunogen corresponds to a synthetic peptide from the human SMRT protein corresponding to amino acids 80-92 (QELHLRPESHSYL).
Clone G9 recognizes the Silencing Mediator for Retinoid and Thyroid receptors (SMRT) gene product, a 168 kDa nuclear protein. Nuclear hormone receptors are transcription factors regulated by ligand binding. In the absence of ligand there is a physical interaction between the nuclear receptors that do not interact with Hsp90 and a family of corepressors which includes SMRT. SMRT helps target histone deacetylases and other components of a multiprotein repressor complex to the specific target promoter to silence gene transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.