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Invitrogen
NDUFS2 Polyclonal Antibody
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Product Details
PA5-19342
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans,
Human,
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (SRGVRQWQPDVE) corresponding to the internal amino acids of NDUFS2 (aa 31-42).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, canine, porcine and rabbit based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase. Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CI-49kD; comp; complex 1, mitochondrial respiratory chain, 49-KD subunit; complex I 49kDa subunit; Complex I-49kD; NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; NADH-coenzyme Q reductase; NADH-ubiquinone oxidoreductase 49 kDa subunit; NADH-ubiquinone oxidoreductase NDUFS2 subunit; ndufs2 {ECO:0000312|EMBL:AAH82067.1}
Gene Aliases: AL033311; CI-49; NDUFS2
UniProt ID: (Human) O75306, (Mouse) Q3TNA8, (Rat) Q641Y2
Entrez Gene ID: (Human) 4720, (Mouse) 226646, (Rat) 289218
NADH dehydrogenase activity
protein binding
NADH dehydrogenase (ubiquinone) activity
electron carrier activity
ubiquitin protein ligase binding
metal ion binding
quinone binding
NAD binding
4 iron, 4 sulfur cluster binding
oxidoreductase activity
oxidoreductase activity, acting on NAD(P)H
iron-sulfur cluster binding
molecular_function
oxidoreductase
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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