Search

  • Fale Conosco
  • Pedido rápido

Bethyl Laboratories

NEDD4L Polyclonal Antibody

View all (22) NEDD4L antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
NEDD4L Polyclonal Antibody

Product Details

A302-512A

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:10,000
-

Immunoprecipitation (IP)

2-5 µg/mg lysate
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 225 and 275 of human neural precursor cell expressed, developmentally down-regulated 4-like.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.20 mg/mL

Amount

20 µg

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.0 to 8.0, with 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Based on 100% sequence identity, this antibody is predicted to react with Orangutan

Target Information

NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: alternatively spliced; amino-terminal variant; developmentally down-regulated 4-like; E3 ubiquitin-protein ligase NEDD4-like; FLJ33870; HECT-type E3 ubiquitin transferase NED4L; KIAA0439; Nedd4-2; NEDD4.2; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4b; similar to NEDD4; ubiquitin-ligase; neural precursor cell expressed, developmentally down-regulated 4-like protein; ubiquitin-protein ligase Rsp5; unnamed protein product

View more View less

Gene Aliases: 1300012C07Rik; hNEDD4-2; KIAA0439; NEDD4-2; NEDD4.2; Nedd4b; NEDD4L; NEDL3; PVNH7; RSP5

View more View less

UniProt ID: (Human) Q96PU5

View more View less

Entrez Gene ID: (Human) 23327, (Mouse) 83814

View more View less

Function(s)
ubiquitin-protein transferase activity protein binding transferase activity sodium channel regulator activity potassium channel inhibitor activity sodium channel inhibitor activity ion channel binding ubiquitin protein ligase activity UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity potassium channel regulator activity ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity ubiquitin-protein ligase
Process(es)
regulation of membrane depolarization ubiquitin-dependent protein catabolic process protein monoubiquitination ion transport neuromuscular junction development protein ubiquitination cell differentiation neuron projection development receptor internalization regulation of protein stability receptor catabolic process ion transmembrane transport regulation of membrane potential proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process regulation of dendrite morphogenesis regulation of synapse organization regulation of membrane repolarization regulation of biological quality protein K48-linked ubiquitination ventricular cardiac muscle cell action potential sodium ion import across plasma membrane negative regulation of potassium ion transmembrane transport regulation of sodium ion transmembrane transport negative regulation of sodium ion transmembrane transport negative regulation of potassium ion export across plasma membrane negative regulation of sodium ion import across plasma membrane positive regulation of dendrite extension negative regulation of protein localization to cell surface positive regulation of caveolin-mediated endocytosis negative regulation of systemic arterial blood pressure response to salt stress response to metal ion positive regulation of sodium ion transport negative regulation of sodium ion transport regulation of ion transmembrane transport protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transmembrane transporter activity negative regulation of sodium ion transmembrane transporter activity regulation of bicellular tight junction assembly positive regulation of cation channel activity
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support