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Bioss
NFAT1 Polyclonal Antibody
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Product Details
BS-4246R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human NFAT1, amino acids 451-550.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The nuclear factor of activated T-cells (NFAT) transcription complex is required for the expression of a group of proteins that collectively regulate the immune response. Four NFAT proteins, encoded on separate genes and expressed as several splice variants, have been described: NFAT1 (also known as NFATp or NFATc2), NFAT2 (NFATc or NFATc1), NFAT3, and NFAT4 (NFATx or NFATc3). These proteins show a low level of sequence similarity with the Dorsal/Rel/NFkB family of transcription factors. Another NFAT-related protein termed NFAT5 differs from isoforms 1-4 in that it lacks many of the Fos/Jun contact sites observed in its predecessors and its subcellular localization is not calcineurin-dependent.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IB-IXL; KIAA0611; NF-ATc2; NF-ATp; NFAT pre-existing s; NFAT pre-existing subunit; NFAT transcription complex, preexisting component; Nuclear factor of activated T-cells, cytoplasmic 2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; nuclear factor of activated T-cells, preexisting component; OTTHUMP00000031291; preexisting nuclear factor of activated T-cells 2; T cell transcription factor NFAT1; T-cell transcription factor NFAT1; transcription factor; unnamed protein product
Gene Aliases: AI607462; JCOSL; NF-ATc2; NF-ATp; NFAT1; NFAT1-D; NFATC2; NFATP
UniProt ID: (Human) Q13469, (Mouse) Q60591
Entrez Gene ID: (Human) 4773, (Rat) 311658, (Mouse) 18019
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
phosphatase binding
sequence-specific DNA binding
binding, bridging
14-3-3 protein binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
molecular_function
transcription factor binding
transcription regulatory region DNA binding
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
response to xenobiotic stimulus
gene expression
positive regulation of gene expression
myotube cell development
cell migration
positive regulation of B cell proliferation
calcineurin-NFAT signaling cascade
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
B cell receptor signaling pathway
cartilage development
cellular response to calcium ion
lncRNA transcription
positive regulation of myoblast fusion
negative regulation of vascular smooth muscle cell differentiation
cytokine production
biological_process
response to drug
transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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