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Invitrogen
NFATC2IP Polyclonal Antibody
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Product Details
PA5-65805
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human NFATC2IP. Recombinant protein control fragment (Product #RP-106479).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SPWKTKLRTKD KEEKKKTEFL DLDNSPLSPP SPRTKSRTHT RALKKLSEVN KRLQDLRSCL SPKPPQGQEQ QGQEDEVVLV E
Highest antigen sequence identity to the following orthologs - mouse 67%, rat 69%.
Target Information
In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; NFATC2-interacting protein; Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
Gene Aliases: ESC2; NFATC2IP; NIP45; RAD60
UniProt ID: (Human) Q8NCF5
Entrez Gene ID: (Human) 84901
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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