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Proteintech
NFE2 Polyclonal Antibody
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Product Details
11089-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NFE2 Fusion Protein Ag1570 (1-373 aa encoded by BC005044)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This is a rabbit polyclonal antibody raised against full-length NFE2 of human origin.
Immunogen sequence: MSPCPPQQS RNRVIQLSTS ELGEMELTWQ EIMSITELQG LNAPSEPSFE PQAPAPYLGP PPPTTYCPCS IHPDSGFPLP PPPYELPAST SHVPDPPYSY GNMAIPVSKP LSLSGLLSEP LQDPLALLDI GLPAGPPKPQ EDPESDSGLS LNYSDAESLE LEGTEAGRRR SEYVEMYPVE YPYSLMPNSL AHSNYTLPAA ETPLALEPSS GPVRAKPTAR GEAGSRDERR ALAMKIPFPT DKIVNLPVDD FNELLARYPL TESQLALVRD IRRRGKNKVA AQNCRKRKLE TIVQLERELE RLTNERERLL RARGEADRTL EVMRQQLTEL YRDIFQHLRD ESGNSYSPEE YALQQAADGT IFLVPRGTKM EATD (1-373 aa encoded by BC005044)
Target Information
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Leucine zipper protein NF-E2; nuclear factor (erythroid-derived 2), 45kD; nuclear factor (erythroid-derived 2), 45kDa; Nuclear factor, erythroid-derived 2 45 kDa subunit; p45 NF-E2; Transcription factor NF-E2 45 kDa subunit
Gene Aliases: NF-E2; NFE2; p45
UniProt ID: (Human) Q16621
Entrez Gene ID: (Human) 4778
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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