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This antibody detects endogenous protein at a molecular weight of 47 kDa (NFIB) and 56 kDa (NFIA, NFIC, NFIX).
Purity is >95% by SDS-PAGE.
NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain, and activates transcription through a putatively novel, proline-rich, carboxy terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, alpha-globin, HSP 70, GRP 78, Histone H1, myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CCAAT-binding transcription factor; CCAAT-box-binding transcription factor; CTF; NF-I/A; NF-I/B; NF-I/C; NF-I/X; NF1-A; NF1-B; NF1-C; NF1-X; NF1-X1 protein; NFI-A; NFI-C; Nuclear factor 1 A-type; Nuclear factor 1 B-type; Nuclear factor 1 C-type; Nuclear factor 1 X-type; nuclear factor 1-C2; nuclear factor 1/A; nuclear factor 1/B; nuclear factor 1/C; nuclear factor 1/X; Nuclear factor I/A; Nuclear factor I/B; Nuclear factor I/C; nuclear factor I/C (CCAAT-binding transcription factor); Nuclear factor I/X; nuclear factor I/X (CCAAT-binding transcription factor); olfactory epithelium nuclear factor I-B; olfactory epithelium nuclear factor I-C; TGGCA-binding protein
Gene Aliases: 1110019L22Rik; 1110047K16Rik; 1500041O16Rik; 6720429L07Rik; 9430022M17Rik; AA589446; AI746521; CTF; CTF5; E030026I10Rik; HMGIC/NFIB; KIAA1439; MRSHSS; NF-I; NF-I/A; NF-I/B; NF-I/X; NF1-A; NF1-B; NF1-C; NF1-X; NF1A; Nf1l21; NFI; NFI-A; NFI-B; NFI-L; NFI-RED; NFI-X; NFIA; NFIB; NFIB2; NFIB3; NFIC; NFIX; SOTOS2